Development of mouse model susceptible to radiation-induced carcinogenesis at low dose and low dose rate and evaluation of radiation-induced cancer risk

2015 Fiscal Year Final Research Report

• Project/Area Number: 25281020
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Hiroshima University
• Principal Investigator: Kamiya Kenji 広島大学, 原爆放射線医科学研究所, 教授 (60116564)
• Co-Investigator(Kenkyū-buntansha): SASATANI MEGUMI 広島大学, 原爆放射線医科学研究所, 助教 (80423052) ; IIZUKA DAISUKE 広島大学, 原爆放射線医科学研究所, 助教 (00455388)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ゲノム障害 / ゲノム修復 / 放射線 / 発がん / 小腸腫瘍 / 突然変異

Outline of Final Research Achievements

ApcMin/+ mice develop spontaneously many intestinal adenomas and are also highly susceptible to radiation. The objective of the current projects was, by utilizing these characteristics of ApcMin/+ mice, to develop a mouse model suitable for the study of radiation-induced cancer risk at low doses and low dose rates. We explored dose rate effects and the effect of genetic background on low dose rate radiation-induced carcinogenesis. We clarified that the genetic background plays a role in dose rate effects on radiation-induced carcinogenesis. Furthermore, we developed a mouse model susceptible to radiation-induced carcinogenesis by using knockout mice that have deficient post-replication repair compared with ApcMin/+ mice.

Free Research Field

放射線生物学，　放射線発がん