Elucidation of next-generation toxicity having highly detective and concetrated homeostatic disruptive chemicals in human and food

2015 Fiscal Year Final Research Report

• Project/Area Number: 25281032
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Environmental impact assessment
• Research Institution: Setsunan University
• Principal Investigator: Ohta Souichi 摂南大学, 薬学部, 教授 (10213729)
• Co-Investigator(Kenkyū-buntansha): KAKUTANI HIDEKI 摂南大学, 薬学部, 助教 (00581414) ; EMA AKIYAMA 摂南大学, 薬学部, 助教 (50581401)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 内分泌攪乱 / 性ホルモン / ダイオキシン / PFOS / 恒常性攪乱

Outline of Final Research Achievements

There are yet many any questions about the toxicity influence on highly advanced functions such as sex hormone secretion or the immune system in human body by environmental pollutants intake with a very small amount from food. In this study, when we administrated PFOS or TCDD to mice each, it was analyze in sex hormone levels in the blood and evaluate their disruption effect As a result, if we assumed a biosynthesis pathway to Androgen and Estrogen which went by way of Progestin from Cholesterol, it was estimated the sex hormone disruption effect having PFOS and TCDD exist the Androgen synthetic pathway side more downstream than Progestin located upstream of the synthetic pathway.

Free Research Field

環境学