2016 Fiscal Year Final Research Report
The roles of methylxanthine derivative on prevention of several disorders
| Project/Area Number |
25282021
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
紫藤 治 島根大学, 医学部, 教授 (40175386)
谷内江 昭宏 金沢大学, 医学系, 教授 (40210281)
少作 隆子 金沢大学, 保健学系, 教授 (60179025)
平田 耕造 神戸女子大学, 家政学部, 教授 (70110624)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 栄養 / 嗜好食品 / がん化予防 / 老化予防 / 認知予防 |
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| Outline of Final Research Achievements |
Theobromine, which is a caffeine derivative, is the primary methylxanthine produced by Theobroma cacao. Mice were fed a diet supplemented with 0.05% theobromine for 30 days. The theobromine-fed (TB) mice performed better on the three-lever task than the control (CN) mice did. Brain-derived neurotrophic factor (BDNF) in brain were higher in the TB mice compared with those in the CN mice. BDNF supports cell survival and neuronal functions, including learning and memory. These results strongly suggested that orally administered theobromine augmented the motor learning in mice.
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| Free Research Field |
予防生理学
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