The roles of methylxanthine derivative on prevention of several disorders
| Project/Area Number | 25282021 |
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
紫藤 治 島根大学, 医学部, 教授 (40175386)
谷内江 昭宏 金沢大学, 医学系, 教授 (40210281)
少作 隆子 金沢大学, 保健学系, 教授 (60179025)
平田 耕造 神戸女子大学, 家政学部, 教授 (70110624)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed(Fiscal Year 2016)
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| Budget Amount *help |
¥18,980,000 (Direct Cost : ¥14,600,000、Indirect Cost : ¥4,380,000)
Fiscal Year 2016 : ¥2,730,000 (Direct Cost : ¥2,100,000、Indirect Cost : ¥630,000)
Fiscal Year 2015 : ¥5,330,000 (Direct Cost : ¥4,100,000、Indirect Cost : ¥1,230,000)
Fiscal Year 2014 : ¥4,940,000 (Direct Cost : ¥3,800,000、Indirect Cost : ¥1,140,000)
Fiscal Year 2013 : ¥5,980,000 (Direct Cost : ¥4,600,000、Indirect Cost : ¥1,380,000)
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| Keywords | 栄養 / 嗜好食品 / がん化予防 / 老化予防 / 認知予防 / 食品 / 栄養学 / 生理学 |
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| Outline of Final Research Achievements |
Theobromine, which is a caffeine derivative, is the primary methylxanthine produced by Theobroma cacao. Mice were fed a diet supplemented with 0.05% theobromine for 30 days. The theobromine-fed (TB) mice performed better on the three-lever task than the control (CN) mice did. Brain-derived neurotrophic factor (BDNF) in brain were higher in the TB mice compared with those in the CN mice. BDNF supports cell survival and neuronal functions, including learning and memory. These results strongly suggested that orally administered theobromine augmented the motor learning in mice.
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Report
(5results)
Research Products
(42results)
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[Journal Article] Long-term Heat Exposure Prevents Hypoxia-Induced Apoptosis in Mouse Fibroblast Cells2014
Author(s)
Sugimoto N, Shido O, Matsuzaki K, Katakura M, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
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Journal Title
Cell biochemistry and biophysics
Volume : (in press)
Pages : 301-7
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Theobromine, the primary methylxanthine found in Theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclear factor-kappa B2014
Author(s)
Sugimoto N, Miwa S, Hitomi Y, Nakamura H, Tsuchiya H, Yachie A
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Journal Title
Nutr Cancer
Volume : 66(3)
Pages : 419-23
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats2013
Author(s)
Sugimoto N, Matsuzaki K, Ishibashi H, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Sekine J, Koizumi S, Yachie A, Umehara H and Shido O
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Journal Title
Scientific Reports
Volume : 3
Pages : 1763-1763
DOI
Related Report
Peer Reviewed
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[Journal Article] Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy2013
Author(s)
Miwa S, Yano S, Tome Y, Sugimoto N, Hiroshima Y, Uehara F, Mii S, Kimura H, Hayashi K, Efimova EV, Fujiwara T, Tsuchiya H, Hoffman RM
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Journal Title
J Cell Biochem
Volume : 114(11)
Pages : 2454-60
DOI
Related Report
Peer Reviewed
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[Presentation] 低酸素環境が細胞に与える影響2014
Author(s)
杉本直俊、松崎健太郎、片倉賢紀、紫藤治
Organizer
第53回日本生気象学会大会
Place of Presentation
桐蔭横浜大学（神奈川県横浜市）
Year and Date
2014-10-24 – 2014-10-25
Related Report
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[Presentation] Theobromine, the primary methylxanthine found in Theobroma cacao, inhibits malignant glioblastoma cell growth by negatively regulating Akt/mammalian target of rapamycin kinase.2014
Author(s)
Sugimoto N, Miwa S, Katakura M, Matsuzaki K, Shido O, Tsuchiya H, Yachie A.
Organizer
EB2014
Place of Presentation
San Diego Convention Center, San Diego, CA, USA
Year and Date
2014-04-26 – 2014-04-30
Related Report
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[Presentation] 食と若返り
Author(s)
杉本直俊
Organizer
第一回「食と環境、そして高齢化を考える研究会」
Place of Presentation
ホテル日航金沢（金沢市）
Related Report
Invited
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