2015 Fiscal Year Final Research Report
The development of new biomarkers to assess the dietary environments concerned to the phosphorus metabolic abnormalities in the diabetic end-stage renal diseases
| Project/Area Number |
25282025
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | University of Hyogo |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ITO MIKIKO 兵庫県立大学, 環境人間学部, 教授 (50314852)
NITTA YOKO 岡山県立大学, 保健福祉学部, 准教授 (70403318)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 糖尿病末期腎症 / 高リン血症 / 血管内皮機能 / リン代謝マーカー |
|---|
| Outline of Final Research Achievements |
The validity of the processed food frequency questionnaire (PFFQ) to estimate amount of phosphorus intake used in this study was verified. The amounts of phosphorus estimated by the PFFQ were correlated with those calculated from diet-records, which showed the validity of this questionnaire.
In this study we investigated the effect of inorganic phosphorus containing in foods as additives on the phosphorus metabolism and the vascular endothelial function. The test meals rich in inorganic phosphorus or organic phosphorus were administered to the subjects, and then the Flow Mediated Dilation (FMD) and the phosphorus metabolic markers were measured. After intake of the high inorganic phosphorus meal, plasma phosphorus level was significantly elevated, and the FMD was deteriorated, compared with the high organic phosphorus meal. It was suggested that ingestion of inorganic phosphorus contained as food additives impaired the vascular endothelial function.
|
| Free Research Field |
病態栄養学（代謝疾患）
|
