Precise construction of single siRNA-loaded self-assemblies for siRNA delivery

2016 Fiscal Year Final Research Report

• Project/Area Number: 25282141
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: The University of Tokyo
• Principal Investigator: Miyata Kanjiro 東京大学, 工学(系)研究科(研究院), 准教授 (50436523)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 核酸医薬デリバリー / siRNA / ブロック共重合体 / ポリイオンコンプレックス

Outline of Final Research Achievements

This study aimed to develop an "siRNA carrier" that allows for safe and efficient siRNA delivery to solid tumors. Particularly, a single siRNA-loaded polyion complex, termed unit PIC, was constructed as a smallest delivery formulation featuring high tissue permeability. The obtained results demonstrated that 1) fine-tuning of the chemical structure and chain length of block catiomers enabled the selective formation of unit PICs, and 2) the optimized unit PIC exerted the excellent blood circulation property and tumor accumulation profile, leading to the enhanced antitumor activity.

Free Research Field

ドラッグデリバリーシステム