Study of anticancer Pt complexes involving with non-covalent interactions and its application for drug

2016 Fiscal Year Final Research Report

• Project/Area Number: 25288027
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Inorganic chemistry
• Research Institution: Kanazawa University
• Principal Investigator: ODANI Akira 金沢大学, 薬学系, 教授 (60143913)
• Co-Investigator(Renkei-kenkyūsha): OGAWA Kazuma 金沢大学, 新学術創成研究機構, 准教授 (30347471) ; KIWADA Tatto 金沢大学, 医薬保健研究域薬学系, 助教 (50414131) ; SHINOHARA Atsushi 大阪大学, 理学研究科, 教授 (60183050) ; YOSHIMURA Takashi 大阪大学, RIセンター, 教授 (90323336) ; TSUCHIYA Hiroyuki 金沢大学, 医薬保健研究域医学系, 教授 (40227434) ; YAMAMOTO Norio 金沢大学, 医薬保健研究域医学系, 特任教授 (90332668) ; MATSUNAGA Tsukasa 金沢大学, 医薬保健研究域薬学系, 教授 (60192340)
• Research Collaborator: SIGEL Helmut ; JASTRZAB Renata ; MESSORI Luigi ; IGARASHI Kentaro
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 非共有性相互作用 / 混合配位子白金錯体 / 白金抗がん剤 / シスプラチン / ドラッグデリバリー / 低副作用 / ＰＤＴ / 金属ポルフィリン錯体

Outline of Final Research Achievements

Mixed ligand Pt complexes involving aromatic ring stacking revealed excellent antitumor effect and low side effect. The hydrogen bond between the phosphate and the amine was useful for bone delivery and low side effect. The Pt complexes with the metal-porphyrin showed pronounced antitumor effect activated by the light. These indicated the non-covalent interaction could play in dynamic biological process, and the introduction of non-covalent interaction into the metal complex is a useful tool for metal-drug application.

Free Research Field

生物無機化学