Development of dual functional glycoconjugated photosensitive supra molecules for advanced photodynamic therapy and photodynamic diagnosis.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25288028
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Inorganic chemistry
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: YANO Shigenobu 奈良先端科学技術大学院大学, 物質創成科学研究科, 客員教授 (60011186)
• Co-Investigator(Kenkyū-buntansha): KATAOKA Hiromi 名古屋市立大学, 医学(系)研究科(研究院), 准教授 (40381785) ; NARUMI Atsushi 山形大学, 理工学研究科, 准教授 (60443975) ; NOMOTO Akihiro 大阪府立大学, 工学(系)研究科(研究院), 准教授 (60405347) ; NAKAI Misaki 関西大学, 工学部, 准教授 (40527115) ; AKASHI Haruo 岡山理科大学, 自然科学研究所, 教授 (30221708)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 光医療 / 光線力学療法 / 癌 / クロリン / フラーレン / 糖鎖

Outline of Final Research Achievements

Photodynamic therapy (PDT) has attracted much attention as a less invasive method for treating cancer. We have carried out in isolation and characterization of the third generation glycoconjugated chlorins and fullerenes for the advanced photodynamic therapy and photodynamic diagnosis (PDD) as described follows, 1) antitumor effects in gastrointestinal stromal tumors using photodynamic therapy with a novel glucose-conjugated chlorin, 2) a novel photodynamic therapy targeting cancer cells and tumor-associated macrophages, 3) efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy, 4) maltotriose-conjugation to a fluorinated chlorin derivative generating a PDT photosensitizer with improved water-solubility etc.

Free Research Field

生体機能関連化学・錯体化学