2015 Fiscal Year Final Research Report
Fabrication of novel nanofilm products using penetrated phase-separation type nanosheets and nanodiscs
| Project/Area Number |
25289252
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural/Functional materials
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| Research Institution | Waseda University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 機能材料 / 医療材料 / ナノ材料 / ドラッグデリバリー / 高分子薄膜 / ナノシート / ナノディスク / ナノクリスタル |
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| Outline of Final Research Achievements |
Thin films (nanosheets) of tens nanometer thickness from medical polymers has been paid attention as an innovative medical material "nano-adhesive plaster" which can be adhered on the various surfaces of living body. This study aims to establish the fabrication process of multilayered nanosheets where drug micro/nano-crystals or nanodiscs are inserted between a barrier layer and a release layer. The drug permeability of various medical polymers was clarified by using fluorescent model drugs, and its control method was established by using penetrated phase separation. Furthermore, the multilayered nanosheets embedding antibiotic AgSD micro-crystals were prepared and showed significantly higher curing rate of infected partial-thickness burn injury in model mice.
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| Free Research Field |
高分子化学
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