Bio-MEMS with reversible antibody on sensor chip

2015 Fiscal Year Final Research Report

• Project/Area Number: 25289290
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: Tohoku University
• Principal Investigator: Umetsu Mitsuo 東北大学, 工学(系)研究科(研究院), 教授 (70333846)
• Co-Investigator(Kenkyū-buntansha): MATSUI JUN 山形大学, 理学部, 准教授 (50361184) ; NAGAMINE KUNIAKI 東北大学, 大学院工学研究科, 助教 (00551540)
• Co-Investigator(Renkei-kenkyūsha): NISHIZAWA MASAHIKO 東北大学, 大学院工学研究科, 教授 (20273592)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ペプチド / タンパク質 / ナノバイオ

Outline of Final Research Achievements

Microelectromechanical system for biology has the potential for reconstituting chain chemical reaction and protein-protein interaction in cell. However, for the construction of cell in MEMS, The ways to immobilize a protein on a specific position on MEMS and to irrepressibly immobilize proteins on MEMS should be studies. In this study, we evaluated material-binding peptide to the peptide with reversible binding to material surfaces. The peptide could be reversibly bound by the change of ionic strength in solution.

Free Research Field

生体機能化学