Understanding of mechanism underlying primordial follicle formation using a pluripotent stem cell-based model

2016 Fiscal Year Final Research Report

• Project/Area Number: 25290033
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Kyushu University (2014-2016); Kyoto University (2013)
• Principal Investigator: HAYASHI Katsuhiko 九州大学, 医学(系)研究科(研究院), 教授 (20287486)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 卵母細胞 / 多能性幹細胞 / 生殖細胞 / 原始卵胞

Outline of Final Research Achievements

The aim of this research project is to establish a culture system that reproduce formation and maintenance of primordial follicles. This project is particularly unique in the point of using pluripotent stem cells, such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), as a starting material. Reconstitution of primordial follicle formation/maintenance from plruipotent stem cells would be quite beneficial, as genetic manipulations in the cells are quite feasible. The culture system in this project will contribute to understanding of mechanisms underlying primordial follicle formation/maintenance, which will eventually elucidate causes of infertility.

Free Research Field

生殖生物学　幹細胞学