2015 Fiscal Year Final Research Report
Analysis of signaling pathways for liver cancer stem cell maintenance
| Project/Area Number |
25290045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Yokohama City University |
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Principal Investigator |
MAEDA Shin 横浜市立大学, 医学(系)研究科(研究院), 教授 (40415956)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKA Motoyuki 東京大学, 医学部附属病院, 助教 (90518945)
SHIBATA Wataru 横浜市立大学, 先端医科学研究センター, 准教授 (00435819)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 肝臓癌 |
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| Outline of Final Research Achievements |
About 35,000 people every year have died of liver cancer in our country, and treatment for the advanced cancer has not been established yet.
Treatment for the differentiated cancer cells is not enough and it's necessary to understand a peculiar character of a stem cell as the cause of the treatment resistance and the recurrence. In this study, we have made a liver cancer mouse model, established a cell line by a liver cancer 3D culture and analyzed a relationship between epithelial-mesenchymal transition and cancer stemness.
These findings may provide the fundamental materials and technique for development of therapies for cancer stem cells.
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| Free Research Field |
消化器内科学
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