2015 Fiscal Year Final Research Report
Analysis of cell-context dependent features of adhesion molecules for cancer diagnosis
| Project/Area Number |
25290051
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松原 大祐 自治医科大学, 医学部, 准教授 (80415554)
後藤 明輝 秋田大学, 医学(系)研究科(研究院), 教授 (90317090)
櫻井 美佳 東京大学, 医科学研究所, 助教 (80508359)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 分子標的薬 / 薬剤耐性 / 肺線がん / EGFR-TKI |
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| Outline of Final Research Achievements |
MET is a receptor of HGF growth factor and is activated by gene amplification and/or overexpression in various cancer to promote cell growth and epithelial to mesenchymal transition. We have demonstrated that a cell adhesion molecule, CADM1, forms a complex with MET on the raft of the cell membrane and suppresses the MET signaling. CADM1 is known to be often inactivated in various cancer cells in their advanced stages. CADM1 could provide a molecular target to suppress oncogenic signaling of cancer cells to malignant growth.
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| Free Research Field |
分子腫瘍学
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