Development of novel CAR-T cell therapy against cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25290057
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Tumor therapeutics
• Research Institution: Yamaguchi University
• Principal Investigator: TAMADA Koji 山口大学, 医学(系)研究科(研究院), 教授 (00615841)
• Co-Investigator(Kenkyū-buntansha): SAKODA Yukimi 山口大学, 大学院医学系研究科, 助教 (30629754)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: がん免疫 / CAR-T細胞 / 免疫細胞療法 / 遺伝子改変技術

Outline of Final Research Achievements

In this project, we explored anti-tumor therapeutic potential of novel CAR (chimeric antigen receptor)-T cell approach which combines FITC (fluorescein isothiocyanate)-labeled anti-tumor antibodies and anti-FITC CAR-T cells. Our studies demonstrated that the novel approach induces potent cytotoxic activity against tumor cells expressing multiple target molecules, and those harboring heterogeneous antigen expressions. In addition, the novel approach inhibits tumor growth by targeting neo-vasculature in tumor tissues. These results thus indicate superior anti-tumor effects and potent applicability of anti-FITC CAR-T cells as a next generation of cancer immunotherapy.

Free Research Field

がん免疫療法