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2015 Fiscal Year Final Research Report

Development of tumor targeting technology in combination of tumor-homing peptide and nanoparticles

Research Project

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Project/Area Number 25290062
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Tumor therapeutics
Research InstitutionNiigata University (2014-2015)
愛知県がんセンター(研究所) (2013)

Principal Investigator

Kondo Eisaku  新潟大学, 医歯学系, 教授 (30252951)

Co-Investigator(Kenkyū-buntansha) Koga Hironori  久留米大学, 医学部, 教授 (90268855)
Co-Investigator(Renkei-kenkyūsha) Takigawa Nagio  川崎医科大学, 医学部, 教授 (60325107)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsペプチド / 腫瘍 / 膵がん / 胆管がん / 脳腫瘍
Outline of Final Research Achievements

Consequently, peptide-dendrimer or peptide-liposome conjugates showed their accumulation to the liver in vivo, although its maginitude of accumulation was decreased in comparison with those of the dendrimer or liposome alone. Taking this into consideration, we changed the strategy from generating the peptide-nano particle conjugates that enhance the delivery to the target tumor tissues, to obtain the highly efficient tumor-targeting peptides by isolating them from the random peptide library. As a result, we succeeded identifying the novel superior tumor-homing peptides such as pancreatic cancer-homing, bile duct cancer-hoiming, and glioblastoma-homing peptides. Patentapplications for these tumor-targeting peptides have been completed, and we are preparing PCT application now.

Free Research Field

腫瘍病理学

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Published: 2017-05-10  

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