2016 Fiscal Year Final Research Report
Regulation of microRNA genes by Sox transcription factors
| Project/Area Number |
25290066
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genome biology
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| Research Institution | Kochi University of Technology (2015-2016)
Osaka University (2013-2014) |
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Principal Investigator |
Kamachi Yusuke 高知工科大学, 環境理工学部, 教授 (90263334)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 転写因子 / microRNA |
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| Outline of Final Research Achievements |
A microRNA is a small non-coding RNA molecule that plays an important role in cell differentiation and cell proliferation. However, it remains largely unknown how expression of the microRNA gene family is controlled during embryonic development. In this study, we investigated regulation of the microRNA genes including the mir-17-92 cluster gene, which is indispensable for vertebrate embryogenesis and also known as cancer microRNA. We found that Sox transcription factors are involved in the regulation of several microRNA genes.
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| Free Research Field |
分子発生生物学
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