2016 Fiscal Year Final Research Report
Structural biology of multidrug transporters
| Project/Area Number |
25291011
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | X線結晶構造解析 / 膜蛋白質 / 多剤耐性菌 / 膜輸送体 |
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| Outline of Final Research Achievements |
Multidrug efflux transporters recognize and export various toxic compounds, thereby conferring antibiotics resistance to the multidrug-resistance pathogens. Understanding of this substrate recognition and export mechanism by multidrug exporters is important from the point of the view of drug discovery. However, the structural analysis of membrane transporters is very difficult. As a result of recent advance of the structural analysis, several crystal structures of multidrug efflux transporters have been determined, but their resolutions were not enough to understand the biologically important aspects, such as the substrate recognition mechanism. In this research project, we performed the structural and functional analyses of YddG, which was initially identified as an efflux pump of toxic compounds, and then shown to export aromatic amino acids by subsequent researches.
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| Free Research Field |
構造生物学
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