A study on semaphorin-regulated diverse cellular events

2016 Fiscal Year Final Research Report

• Project/Area Number: 25291044
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cell biology
• Research Institution: Nagoya University
• Principal Investigator: Takagi Shin 名古屋大学, 理学(系)研究科(研究院), 准教授 (90171420)
• Co-Investigator(Renkei-kenkyūsha): IHARA Kunio 名古屋大学, 遺伝子実験施設, 准教授 (90223297)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: セマフォリン / 表皮 / エンドサイトシス / シナプトタグミン / 線虫 / 器官形成

Outline of Final Research Achievements

In this study we have studied regulation of vesicle transport by the semaphorin signal in the nematode C. elegans. Through genetic as well as cell-biological analyses, we have demonstrated that semaphorin negatively regulates endocytosis in ray epidermal cells. We also revealed that the synaptotagmin1/Stonin2 system, a well-known regulator of synaptic vesicle recycling in neurons, plays a critical role in vesicle transport in ray epidermal cells. Our study shows importance of participation of the semaphorin-regulated vesicle transport in regulation of the cell shape.

Free Research Field

発生生物学