Regulatory mechanisms and molecular bases of selective mitochondria degradation

2016 Fiscal Year Final Research Report

• Project/Area Number: 25291045
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cell biology
• Research Institution: Osaka University
• Principal Investigator: OKAMOTO Koji 大阪大学, 生命機能研究科, 准教授 (40455217)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: ミトコンドリア / オートファジー / リン脂質メチル化酵素 / タンパク質N末端アセチル化酵素 / 新生ポリペプチド鎖結合因子 / 出芽酵母

Outline of Final Research Achievements

Autophagy-dependent degradation selective for mitochondria, termed mitophagy, is a fundamental mechanism conserved from yeast to humans that contributes to mitochondrial quality and quantity control. In this study, we analyzed yeast mutants and demonstrated that phospholipid methyltransferase, protein N-terminal acetyltransferase, and nascent polypeptide chain-associated factor are important for efficient mitophagy.

Free Research Field

細胞生物学