Molecular Mechanisms of Mitochondrial Fission

2015 Fiscal Year Final Research Report

• Project/Area Number: 25291046
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cell biology
• Research Institution: Kyushu University
• Principal Investigator: Mihara Katsuyoshi 九州大学, 医学(系)研究科(研究院), 名誉教授 (40029963)
• Co-Investigator(Kenkyū-buntansha): OOtera Hidenori 九州大学, 大学院医学研究院, 助教 (40380612)
• Co-Investigator(Renkei-kenkyūsha): ISIHARA NAOTADA 久留米大学, 分子生命科学研究所, 教授 (10325516) ; Noimura Masahisa 九州大学, 大学院医学研究院, 講師 (30315080) ; Masuda Keiji 九州大学, 大学院歯学病院, 講師 (60392122)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ミトコンドリア / ミトコンドリア融合 / ミトコンドリア分裂 / アポトーシス

Outline of Final Research Achievements

Mitochondrial fission-facilitated cytochrome c release from the mitochondrial critae into the cytoplasm constitutes the key step of intrinsic apoptosis, although how the mitochondrial fission GTPase Drp1 and its mitochondrial receptors Fis1, Mff, MiD49, and MiD51 are involved in this reaction remained elusive. We found with the fission factors-KO cell lines that Drp1-dependent mitochondrial fission through MiD49/MiD51, but not through the other factors, regulates cytochrome c release by cristae remodeling during intrinsic apoptosis.

Free Research Field

細胞生物学