The dynamics of X chromosome reactivation in female PGCs

2016 Fiscal Year Final Research Report

• Project/Area Number: 25291076
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Genetics/Chromosome dynamics
• Research Institution: Kyoto University
• Principal Investigator: okamoto ikuhiro 京都大学, 医学(系)研究科(研究院), 講師 (40648424)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: マウス / X染色体 / 再活性化 / 始原生殖細胞

Outline of Final Research Achievements

XX females silence one of their X chromosomes. This involves a process whereby a noncoding RNA known as Xist coats one of the X chromosome. An exception to this occurs in pluripotent lineages, the inner cell mass (ICM) and primordial germ cells (PGCs), where the inactive X undergo reactivation. Analyzing PGC-like cells (PGCLCs) induced from mouse embryonic stem cells (ESCs), we found that hallmarks of the inactive X change, providing a direct readout of X reactivation progression.

Free Research Field

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