2015 Fiscal Year Final Research Report
Molecular mechanisms of chromosomal rearrangement caused by topological changing of DNA.
| Project/Area Number |
25291077
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genetics/Chromosome dynamics
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
Maki Hisaji 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (20199649)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 染色体再編・維持 / 遺伝的不安定性 / 繰り返し配列 |
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| Outline of Final Research Achievements |
Various kinds of repetitive sequence present in genomes of many species are known to be a cause of genetic instability which leads to genetic diseases and cancer. We found that a long inverted repeat is transformed to a cruciform DNA in a manner dependent on DNA replication. E. coli SbcCD appeared to have a novel enzymatic acitivity that cleaves such a cruciform DNA, and this enzyme perhaps causes the genetic instability at long inverted repeats.
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| Free Research Field |
分子遺伝学、生化学
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