Role of PGC1alpha and FOXO1 in skeletal muscle amino acid metabolism, and muscle mass

2015 Fiscal Year Final Research Report

• Project/Area Number: 25292076
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Kyoto Prefectural University
• Principal Investigator: Kamei Yasutomi 京都府立大学, 生命環境科学研究科(系), 教授 (70300829)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨格筋 / 転写調節 / 運動 / 代謝

Outline of Final Research Achievements

A well-balanced body energy budget is controlled by limiting calorie intake and/or increasing energy expenditure, which is typically achieved by appropriate physical exercise, and is the most effective treatment for obesity and diabetes mellitus. In this study, we showed that PGC1α and FOXO1 are critical regulators of amino acid metabolism in skeletal muscle (BCAA and glutamine, respectively). Our aims are to better understand the molecular mechanisms underlying skeletal muscle metabolism, establish novel strategies for the prevention of lifestyle-related diseases and sarcopenia, and establish a fundamental biological basis for the effects of functional foods.

Free Research Field

分子栄養学