Selenium-transport mechanism of selenoprotein P

2016 Fiscal Year Final Research Report

• Project/Area Number: 25292078
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Doshisha University
• Principal Investigator: Saito Yoshiro 同志社大学, 生命医科学部, 准教授 (70357060)
• Co-Investigator(Renkei-kenkyūsha): NOGUCHI Noriko 同志社大学, 生命医科学部, 教授 (40198578) ; TAKAHASHI Kazuhiko 北海道薬科大学, 基礎教育系, 教授 (10113581)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: トランスポーター / セレン / 受容体

Outline of Final Research Achievements

Selenoprotein P (SeP) is plasma selenoprotein containing essential trace element selenium. SeP functions as a transporter of selenium, delivering selenium to the cells. However, details of selenium-transport mechanisms of SeP remain unknown. In the present study, we identified SeP receptors in several tissues such as skeletal muscle, pancreas, and lymphocytes. Further, we identified SeP receptors with different affinity for SeP, and found a different molecular pathway to transport selenium of SeP to the cells. Collectively, we revealed selenium-transport mechanisms of SeP.

Free Research Field

生化学　細胞生物学