Selenium-transport mechanism of selenoprotein P
| Project/Area Number |
25292078
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Doshisha University |
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Principal Investigator |
Saito Yoshiro 同志社大学, 生命医科学部, 准教授 (70357060)
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| Co-Investigator(Renkei-kenkyūsha) |
NOGUCHI Noriko 同志社大学, 生命医科学部, 教授 (40198578)
TAKAHASHI Kazuhiko 北海道薬科大学, 基礎教育系, 教授 (10113581)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | トランスポーター / セレン / 受容体 / 膵β細胞 / インスリン / 中和抗体 / セレノプロテイン / 栄養生化学 / 糖尿病 / 細胞内輸送 / リソソーム / 回収エンドソーム / 酸化ストレス / セレノプロテインP / セレン運搬作用 / クロスリンカー |
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| Outline of Final Research Achievements |
Selenoprotein P (SeP) is plasma selenoprotein containing essential trace element selenium. SeP functions as a transporter of selenium, delivering selenium to the cells. However, details of selenium-transport mechanisms of SeP remain unknown. In the present study, we identified SeP receptors in several tissues such as skeletal muscle, pancreas, and lymphocytes. Further, we identified SeP receptors with different affinity for SeP, and found a different molecular pathway to transport selenium of SeP to the cells. Collectively, we revealed selenium-transport mechanisms of SeP.
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Report
(5 results)
Research Products
(49 results)
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[Journal Article] Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle.2017
Author(s)
H Misu, H Takayama, Y Saito, Y Mita, A Kikuchi, K Ishii, K Chikamoto, T Kanamori, N Tajima, F Lan, Y Takeshita, M Honda, M Tanaka, S Kato, N Matsuyama, Y Yoshioka, Iwayama K, Tokuyama K, Akazawa N, Maeda S, Takekoshi K, Matsugo S, Noguchi N, S Kaneko, T Takamura.
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Journal Title
Nature Med
Volume: 23
Issue: 4
Pages: 508-516
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox.2017
Author(s)
Bharatwaj Sowrirajan, Yoshiro Saito, Deepak Poudyal, Qian Chen, Hongyan Sui, Suk See DeRavin, Hiromi Imamichi, Toyotaka Sato, Douglas B. Kuhns, Noriko Noguchi, Harry L. Malech, H. Clifford Lane and Tomozumi Imamichi
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 43441-43441
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients.2016
Author(s)
Y. Saito, Y. Akazawa-Ogawa, A. Matsumura, K. Saigoh, S. Itoh, K. Sutou, M. Kobayashi, Y. Mita, M. Shichiri, S. Hisahara, Y. Hara, H. Fujimura, H. Takamatsu, Y. Hagihara, Y. Yoshida, T. Hamakubo, S. Kusunoki, S. Shimohama, N. Noguchi
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Journal Title
Sci Rep
Volume: 29
Issue: 1
Pages: 30793-30793
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Development of a Sol Particle Homogeneous Immunoassay for Measuring Full-Length Selenoprotein P in Human Serum.2016
Author(s)
M. Tanaka, Y. Saito, H. Misu, S. Kato, Y. Kita, Y. Takeshita, T. Kanamori, T. Nagano, M. Nakagen, T. Urabe, T. Takamura, S. Kaneko, K. Takahashi and N. Matsuyama.
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Journal Title
J Clin Lab Anal
Volume: 30
Issue: 2
Pages: 114-122
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance2014
Author(s)
Fei Lan, H Misu, K Chikamoto, H Takayam, A Kikuchi, K Mohri, N Takata, H Hayashi, N Matsuzawa-Nagata, Y Takeshita, H Noda, Y Matsumoto, T Ota, T Nagano, M Nakagen, K Miyamoto, K Takatsuki, T Seo, K Iwayama, K Tokuyama, S Matsugo, H Tang, Y Saito, S Yamagoe, S Kaneko, T Takamura
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Journal Title
Diabete
Volume: 63
Issue: 5
Pages: 1649-1664
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.2014
Author(s)
Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
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Journal Title
Diabetologia
Volume: 57
Issue: 9
Pages: 1968-1976
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Metformin Suppresses Expression of the Selenoprotein P gene via an AMPK-FoxO3a Pathway in H4IIEC3 Hepatocytes.2013
Author(s)
Hiroaki Takayama, Hirofumi Misu, Hisakazu Iwama, Keita Chikamoto, Yoshiro Saito, Koji Murao, Atsushi Teraguchi, Fei Lan, Akihiro Kikuchi, Reina Saito, Natsumi Tajima, Takayoshi Shirasaki, Seiichi Matsugo, Ken-ichi Miyamoto, Shuichi Kaneko, and Toshinari Takamura
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Journal Title
Journal of Biological Chemistry,
Volume: 289
Pages: 335-345
Related Report
Peer Reviewed
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