The analysis of interaction of chemerin and other adipokines in bovine fat accumulation and lipid metabolim

2015 Fiscal Year Final Research Report

• Project/Area Number: 25292158
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Animal production science
• Research Institution: Tohoku University
• Principal Investigator: ROH SANGGUN 東北大学, (連合)農学研究科(研究院), 准教授 (90322130)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Kei-ichi 東北大学, 大学院農学研究科, 教授 (10344706) ; Nakajima Kei-ichi 国立研究開発法人 農業・食品産業技術総合研究機構, 主任研究員 (70362150) ; HAGINO Akihiko 東北大学, 大学院農学研究科, 助教 (80156249) ; HAGA Satoshi 国立研究開発法人 農業・食品産業技術総合研究機構, 研究員 (90442748)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ウシ / Chemerin / Weaning / Lactation dairy cattle

Outline of Final Research Achievements

This study was aimed to elucidate the physiological function of chemerin in the metabolism transitional period of weaning and lactating dairy cattle. Protein expression of Chemerin in the liver was reduced after weaning, but chemerin regulated the gluconeogenesis by propionic acid in the liver without the regulation of insulin secretion in the weaning period. Chemerin gene expression and secretion was reduced in liver of dairy cows after delivery, but this change is directly related with the regulation hepatic gluconeogenesis. This results suggest that the expression and secretion of chemerin in cattle dynamically changes the metabolism transition and revealed to be involved in the regulation of lipid metabolism or glucose metabolism.

Free Research Field

動物生理学