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2016 Fiscal Year Final Research Report

Selection and functionality of candidate strains for probiotics in terms of co-evolution with host livestock

Research Project

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Project/Area Number 25292165
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Animal production science
Research InstitutionKyoto Prefectural University

Principal Investigator

Ushida Kazunari  京都府立大学, 生命環境科学研究科(系), 教授 (50183017)

Co-Investigator(Kenkyū-buntansha) 大熊 盛也  国立研究開発法人理化学研究所, その他部局等, その他 (10270597)
丸山 史人  京都大学, 医学(系)研究科(研究院), 准教授 (30423122)
Co-Investigator(Renkei-kenkyūsha) TSUKAHARA Takamitsu  京都府立大学, 大学院生命環境科学研究科, 特任講師 (90562091)
INOUE Ryo  京都府立大学, 大学院生命環境科学研究科, 講師 (70443926)
Research Collaborator TSUCHIDA Sayaka  京都府立大学, 大学院生命環境科学研究科, 特任講師 (40734687)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords共進化 / 腸内細菌 / ブタ / イノシシ
Outline of Final Research Achievements

Probiotics for livestock become popular, but most of products were derived from human-oriented products without verification in livestock. We isolated intestinal bacteria, which co-evolved with host pig during evolution of Suidae.We collected fresh feces from various animals of Suidae: domestic pigs (Japan and Africa), wild boar in Japan in wild or captivity, Red-river hogs and Worthogs in wild or captivity. NGS-metagenome was done to identify dietary- and host-effect. Bifidobacterium thermascidophilum and Lactobacillus mucosae were identified as Suidae-specific lactic acid bacteria and L. amylovorus is one became predominant with cereal feeding. Among co-evolved lactic acid bacteria, B. thermacidophilum often acquired tetracycline resistance, suggesting inappropriateness of Bifidobacterium as probiotics in pigs. L. mucosae is a better candidate of probiotics for pigs; one strain showed anti-pathogenic activity.

Free Research Field

動物生理学

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Published: 2018-03-22  

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