Studies on developmental stage specific gene expression regulation and metacyclogenesis in African trypanosomes

2015 Fiscal Year Final Research Report

• Project/Area Number: 25292167
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Obihiro University of Agriculture and Veterinary Medicine
• Principal Investigator: Inoue Noboru 帯広畜産大学, 原虫病研究センター, 教授 (10271751)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アフリカトリパノソーマ / ライフサイクル / 細胞分化 / 遺伝子 / 転写翻訳制御 / ツェツェバエ

Outline of Final Research Achievements

In this research project, we have investigated in detail mechanisms of stage-specific gene expression regulation in African trypanosomes, which cause animal trypanosomoses, such as animal African trypanosomoses, Surra and Dourine. As a result, we have found that gene expression of congolense epimastigote specific protein (cesp) was regulated by cis-elements located in the 3UTR. In addition we found a novel epimastigote stage-specific hemoglobin receptor (TcEpHbR), which could be a novel target gene for development of trypanocidal drugs and vaccines against animal trypanosomoses.

Free Research Field

原虫病学