Molecular mechanism of host-transition in vecotr-borne pathogens

2016 Fiscal Year Final Research Report

• Project/Area Number: 25292168
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Obihiro University of Agriculture and Veterinary Medicine
• Principal Investigator: FUKUMOTO SHINYA 帯広畜産大学, 原虫病研究センター, 准教授 (50376422)
• Co-Investigator(Kenkyū-buntansha): 井上 昇 帯広畜産大学, 原虫病研究センター, 教授 (10271751)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: ベクター / マラリア

Outline of Final Research Achievements

Vector-borne pathogens such as malaria parasite or filaria transit between biologically different hosts of mammals and arthropods. Host path conversion is an important event for pathogens and is essential for adapting to the parasitic environment and establishing transmission. Therefore, in this study, we aimed to clarify the host transformation adaptation mechanism in infection establishment. As a result of analyzing host transformation related genes identified by the applicants, it was revealed that the two host transformation points of the vector infectious stage and the host infectivity stage are controlled by the same gene. We also screened novel host transformation related genes and developed methods for producing genetically modified protozoa.

Free Research Field

獣医学