2015 Fiscal Year Final Research Report
Development of therapeutic agents and vaccines against feline infectious peritonitis
| Project/Area Number |
25292183
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Takano Tomomi 北里大学, 獣医学部, 准教授 (20525018)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 猫伝染性腹膜炎 / ワクチン / 抗ウイルス薬 / TNF-α / コロナウイルス |
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| Outline of Final Research Achievements |
Feline infectious peritonitis (FIP) is a virus-induced fatal disease in cats. There have been no reports on agents that have exhibited therapeutic or preventive effects. On the basis of these facts, we have tried to develop therapeutic agents and vaccines against FIP. We selected peptides that strongly induced Th1 activity from the peptides derived from FIPV structural proteins. Prevention against FIPV-induced FIP was slightly better in SPF cats treated with peptides derived from the structural protein of FIPV. We have prepared monoclonal antibodies (MAb) that neutralize feline TNF-α(MAb 2-4).Progression to FIP was prevented in 2 out of 3 cats treated with MAb 2-4. These results may provide important information for the development of therapeutic agents and vaccines against FIP.
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| Free Research Field |
獣医感染症学、獣医ウイルス学
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