2015 Fiscal Year Final Research Report
Search for natural molecules that control memory and pain from medicinal resources and drug development reserach
| Project/Area Number |
25293023
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Natural medicines
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
北島 満里子 千葉大学, 薬学研究科(研究院), 准教授 (60195261)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 天然活性物質 / 生物活性物質の探索 / 鎮痛剤 / 認知症改善薬 / 全合成 / アルカロイド / 構造活性相関 |
|---|
| Outline of Final Research Achievements |
Search on drug development of new analgesics for cancer pain based on natural molecules were investigated. New indole alkaloid derivatives having potent opioid analgesic activity and good metabolic stability were developed. The total synthesis of C5-nor stemmadenine-type alkaloids with non-opioid analgesic activity was accomplished. Ibooga-type indole alkaloids having potent TRPM8 antagonistic activity were found. To search new acetylcholinesterase inhibitors for development of medicines improving the memory disorders, isolation and asymmetric total syntheses of new Lycopodium alkaloids were achieved.
|
| Free Research Field |
天然資源系薬学
|
