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2017 Fiscal Year Final Research Report

Reverse proteomics of post-translational modifications utilizing small molecules

Research Project

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Project/Area Number 25293027
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Drug development chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

Ishikawa Minoru  東京大学, 分子細胞生物学研究所, 准教授 (70526839)

Project Period (FY) 2013-04-01 – 2018-03-31
Keywords翻訳後修飾
Outline of Final Research Achievements

There is increasing evidence that preparation of target proteins with their post-translational modifications is important to reveal protein functions. We aimed at development of small molecules that induce post-translational modifications including ubiquitination, SUMOylation, and phosphorylation. As results, small molecules that induce the degradation of aggregation-prone proteins were discovered. In addition, transrepression-selective ligands of nuclear receptors, and small molecules that induce phosphorylation of the target protein were also synthesized.

Free Research Field

創薬化学

URL: 

Published: 2019-03-29  

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