Reverse proteomics of post-translational modifications utilizing small molecules

2017 Fiscal Year Final Research Report

• Project/Area Number: 25293027
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: Ishikawa Minoru 東京大学, 分子細胞生物学研究所, 准教授 (70526839)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: 翻訳後修飾

Outline of Final Research Achievements

There is increasing evidence that preparation of target proteins with their post-translational modifications is important to reveal protein functions. We aimed at development of small molecules that induce post-translational modifications including ubiquitination, SUMOylation, and phosphorylation. As results, small molecules that induce the degradation of aggregation-prone proteins were discovered. In addition, transrepression-selective ligands of nuclear receptors, and small molecules that induce phosphorylation of the target protein were also synthesized.

Free Research Field

創薬化学