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2015 Fiscal Year Final Research Report

Mechanisms for the navigation of the intracellular transport

Research Project

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Project/Area Number 25293046
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field General anatomy (including histology/embryology)
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Okada Yasushi  国立研究開発法人理化学研究所, 生命システム研究センター, チームリーダー (50272430)

Co-Investigator(Kenkyū-buntansha) Takai Akira  国立研究開発法人理化学研究所, 生命システム研究センター, 基礎科学特別研究員 (60637205)
Shima Tomohiro  独立行政法人理化学研究所, 生命システム研究センター, 基礎科学特別研究員 (60631786)
Ikeda Kazuho  国立研究開発法人理化学研究所, 生命システム研究センター, 研究員 (20642565)
Ito Yoko  国立研究開発法人理化学研究所, 生命システム研究センター, 特別研究員 (60584571)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords細胞内輸送 / 細胞極性 / 微小管 / 分子モーター / キネシン
Outline of Final Research Achievements

The navigation mechanism for the intracellular transport has remained unclear. We are proposing a model that the conformational differences of micorubules between the GTP-bound and GDP-bound state would serve as the directional cue for kinesins that drive the intracellular transport into the neuronal axons. In this study, we have clarified the underlying mechanisms for this transport by the combination of single molecule imaging and the structural analyses.

Free Research Field

生物物理学、細胞生物学

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Published: 2017-05-10  

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