2015 Fiscal Year Final Research Report
Physiological and pathophysiological role of sphingosine-1-phosphate signaling in vascular system
Project/Area Number |
25293050
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
FUKUHARA SHIGETOMO 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (70332880)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | スフィンゴシン-1-リン酸 / Spns2 / 血管 / リンパ管 / 発生 |
Outline of Final Research Achievements |
In this study, we have investigated physiological and pathophysiological role of bioactive lipid mediator sphingosine-1-phosphate (S1P), focusing on its transporter, Spns2. As a result, we found that S1P secreted from endothelial cells through Spns2 promotes endothelial cell-cell junctions in an autocrine manner, thereby maintaining the integrity of lymphatic vessels. In addition, we also investigated the physiological role of S1P in zebrafish development and found that S1P released from yolk syncytial layer through Spns2 induces activation of nuclear transcription factor Yap1 to regulate endoderm formation, which is required for migration of cardiac precursor cells. Therefore, S1P/S1P2/Yap1 signaling regulates cardiac development through endoderm formation.
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Free Research Field |
血管生物学
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