2016 Fiscal Year Final Research Report
Molecular mechanisms of presynaptic differentiation
| Project/Area Number |
25293057
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | University of Toyama |
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Principal Investigator |
YOSHIDA Tomoyuki 富山大学, 大学院医学薬学研究部(医学), 准教授 (90372367)
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| Co-Investigator(Renkei-kenkyūsha) |
UEMURA TAKESHI 信州大学, 医学部, 准教授 (00372368)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | シナプス形成 / シナプスオーガナイザー |
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| Outline of Final Research Achievements |
Presynaptic differentiation is induced by an activation of small subset of cell adhesion molecules called synapse organizers. Using artificially induced hemi-synapses between recombinant synapse organizer-coated beads and cultured neurons, we identified components of presynaptic protein complexes formed on the cytoplasmic domain of synapse organizers on activation. Crystal structural analyses of presynaptic organizer PTPδ in complex with IL1RAPL1, IL-1RAcP or Slitrk2 and mutational analyses of these synapse organizers revealed structure-function relationships of synapse-organizing complexes for presynaptic differentiation.
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| Free Research Field |
分子神経科学
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