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2015 Fiscal Year Final Research Report

Roles of heparan sulfate modification in biological signaling

Research Project

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Project/Area Number 25293065
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field General medical chemistry
Research InstitutionUniversity of Tsukuba

Principal Investigator

Masu Masayuki  筑波大学, 医学医療系, 教授 (20243032)

Co-Investigator(Kenkyū-buntansha) KEINO-MASU Kazuko  筑波大学, 医学医療系, 講師 (50344883)
Co-Investigator(Renkei-kenkyūsha) NAGATA Michio  筑波大学, 医学医療系, 教授 (10192238)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsヘパラン硫酸 / 糖鎖 / スルファターゼ / ノックアウトマウス / 脳 / 腎臓 / 糖尿病
Outline of Final Research Achievements

We performed analysis of heparan sulfate endosulfatases, Sulf1 and Sulf2, in biological signaling by using knockout mice. The double knockout mice showed corticospinal tract defects, including defects in midline crossing at the pyramidal decussation and abnormal trajectory towards the superior colliculus. The double knockout mice also showed slight abnormalities in kidney glomeruli, especially in the mesangial region. Furthermore they showed severer glomerular abnormalities after inducing diabetes mellitus by streptozotocin compared with the wild-type controls.

Free Research Field

神経科学

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Published: 2017-05-10  

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