microRNA controls Src-induced cancer progression

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293077
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Aichi Cancer Center Research Institute (2015); Osaka University
• Principal Investigator: Oneyama Chitose 愛知県がんセンター(研究所), 感染腫瘍学部, 部長 (90373208)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: Src / がん / microRNA

Outline of Final Research Achievements

c-Src is frequently upregulated in various human cancers and believed to play a pivotal role on malignant behavior of cancer cells. However, the molecular mechanism underlying c-Src-mediated tumor progression remains unclear. To address the molecular mechanisms underlying c-Src-mediated tumor progression through the regulation of gene expression, we examined the involvement of miRNAs in the c-Src-mediated cell transformation. Microarray profiling revealed that c-Src activation causes aberrant expression of a limited set of miRNAs. We investigated the function of these miRNAs and uncovered the miRNA-mediated regulation of c-Src oncogenic signaling and interplay between Src signaling and other oncogenic signaling, such as mTOR and focal adhesion-related pathways. Signaling molecules in such pathways are linked to each other, not only via phosphorylation and protein-protein interactions but also via translational regulation by miRNAs.

Free Research Field

分子腫瘍学