2015 Fiscal Year Final Research Report
Search for mechanisms how Helicobacter pylori infection causes gastric cancer
| Project/Area Number |
25293104
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ヘリコバクター・ピロリ / 病原因子 / 胃癌 |
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| Outline of Final Research Achievements |
Helicobacter pylori (both strains TN2GF4 and SS1) could colonize gp130F759 mice, and mice infected with strain TN2GF4 showed severer inflammation than those with strain SS1. Strain TN2GF4 was East Asian-type and strain SS1 was Western-type, supporting the hypothesis that East Asian-type strains were more virulent than Western-type strains. Somewhat surprisingly, isogenic oipA mutants could not colonize the mice, suggesting that OipA plays important roles on colonization and the attachment of H. pylori to the epithelial cells. We also performed the analyses using outer membrane proteins of H. pylori, and showed that OipA formed virulent complex with other unknown virulence factors on the H. pylori surface.
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| Free Research Field |
消化管感染症
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