2015 Fiscal Year Final Research Report
Intracellular transprt of influenza virus genome
| Project/Area Number |
25293107
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kyoto University (2015)
The University of Tokyo |
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Principal Investigator |
Noda Takeshi 京都大学, ウイルス研究所, 教授 (00422410)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | インフルエンザ |
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| Outline of Final Research Achievements |
Influenza virus M2 protein plays an important role in the packaging of influenza virus ribonucleoprotein complexes (RNPs) into progeny virions. Our purpose of this study is to identify M2-interactiong host proteins that are involved in intracellular transport of M2 proteins and RNPs. First we identified that GBF1 interacted with M2 protein. Down regulation of GBF1 specifically inhibited the virus replication. Further experiments revealed that GBF1 is responsible for assembly and virus particle formation, but not for intracellular transport of RNPs.
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| Free Research Field |
ウイルス学
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