Establishment of cancer diagnosis system by multi-platform metabolomics

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293131
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kobe University
• Principal Investigator: YOSHIDA MASARU 神戸大学, 医学(系)研究科(研究院), 准教授 (00419475)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: メタボロミクス / 質量分析計 / バイオマーカー / がん

Outline of Final Research Achievements

In this study, we analyze serum from cancer patients by using gas chromatograph mass spectrometry and liquid chromatograph mass spectrometry, and then validated the possibility for the cancer profiling diagnosis system based on the alterations in the levels of blood metabolites.　We established the four kinds of the analyzing platform for blood metabolites, and then analyzed serum from cancer patients by using these platforms. As a result, we could find the candidates for metabolite biomarkers, and furthermore could suggested the new diagnosis procedure called ‘2-phase screening’.

Free Research Field

医歯薬学