Risk prediction of cardiovascular diseases based on novel retinal vascular imaging biomarkers

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293138
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Yamagata University
• Principal Investigator: Kawasaki Ryo 山形大学, 医学(系)研究科(研究院), 准教授 (70301067)
• Co-Investigator(Kenkyū-buntansha): OIZUMI Toshihide 山形大学, 大学院医学系研究科, 講師 (00344797) ; DAIMON Makoto 弘前大学, 大学院医学系研究科, 教授 (20241698) ; KONTA Tsuneo 山形大学, 医学部, 准教授 (60333952) ; SHIBATA Yoko 山形大学, 医学部, 講師 (60333978)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 予防医学 / 疫学 / 循環器 / 網膜

Outline of Final Research Achievements

Background: Retinal vasculature is unique “window” where vessels can be observed in vivo. Retinal vascular signs have been utilized as a marker to indicate risk of hypertension and arteriolosclerosis. However, there was an issue that inter-rater agreement is not good; thus, quantitative markers have been warranted. Aim: We studies whether newer markers of retinal vasculature by quantifying retinal morphological features. Results: We found that the presence of retinal vascular diseases was associated with higher risk of stroke. Retinal vascular calibre was associated with smoking sensitivity related to deterioration in male smokers, risk of micro-albuminuria, and insulin resistance all associated with the further risk of cardiovascular diseases.

Free Research Field

疫学