• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Annual Research Report

CD44バリアント陽性胃がん幹細胞を特異的に検出するPET診断の開発

Research Project

Project/Area Number 25293178
Research Category

Grant-in-Aid for Scientific Research (B)

Research InstitutionKeio University

Principal Investigator

鈴木 秀和  慶應義塾大学, 医学部, 准教授 (70255454)

Co-Investigator(Kenkyū-buntansha) 村上 康二  慶應義塾大学, 医学部, 教授 (50200267)
芝田 晋介  慶應義塾大学, 医学部, 助教 (70407089)
井上 浩義  慶應義塾大学, 医学部, 教授 (10213175)
Project Period (FY) 2013-04-01 – 2016-03-31
KeywordsCD44v9 / がん幹細胞 / シスチン / グルタチオン / ROS / 胃がん / 5-FU / trastuzumab
Research Abstract

早期胃がんの内視鏡治療時のCD44v9陽性群では有意に異時性胃がん発生が高率であった。CD44陰性胃癌中分化腺癌細胞MKN28にCD44 variant 9 (CD44v9)、コントロールとしてCD44sを強制発現させたCD44v9-MKN28、CD44s-MKN28を作製した。GSH増強薬NAC投与で、MKN28の5-FU感受性は有意に抑制され、5-FU耐性にGSHが関与すると考えられた。また、CD44v9-MKN28は、MKN28、CD44s-MKN28と比べ有意に5-FU耐性を示した。5-FU投与下でMKN28、CD44s-MKN28では濃度依存性にROS誘導・GSH減少が起こったがCD44v9-MKN28では抑制された。xCT阻害物質sulfasalazine投与でCD44v9-MKN28でも5-FUによるROS誘導・GSH減少を認めCD44v9-xCT系による抗酸化能が5-FU耐性に寄与すると考えられた。NOGマウスに各細胞を皮下注し腫瘍形成後に溶媒、5-FU、5-FU+sulfasalazine腹腔内投与の3群に分けた。CD44s-MKN28腫瘍は5-FU投与で縮小したがCD44v9-MKN28では縮小しなかった。5-FU+sulfasalazineではCD44v9-MKN28腫瘍は有意に縮小した。さらに上記細胞をCagA陽性ピロリ菌に曝露したHp-CD44-MKN28細胞を作製した。Hpの有無で細胞周期は両細胞間で有意差は認めなかったが、CD44v9-MKN28ではHp群で有意に遊走能が上昇した。CD44s-MKN28、CD44v9-MKN28共に、Hpで有意な浸潤能亢進を認め、CD44v9-MKN28でより浸潤度が高かった。これらの細胞をNOGマウス背部皮下に移植したところ、CD44v9-MKN28群の移植後腫瘍体積はHp群で有意に高値であった。別系ではCD44v9発現vectorをHER2陽性胃高分化型腺癌細胞NCI-N87に形質転換した(CD44v9-NCI-N87)。NCI-N87ではtrastuzumab用量依存性に細胞生存率は低下しROS蓄積を認めた。CD44v9-NCI-N87ではtrastuzumab投与でも生存率は低下せず、ROS蓄積も認めず、HER2発現細胞でもCD44v9発現でtrastuzumab耐性を獲得することが示された。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

CD44v9陽性胃がん幹細胞の抗がん療法(S-1, trastuzumab)に対する耐性の分子機序を詳細に検討し、CD44v9発現によるシスチントランスポーターであるxCTの安定化によるシスチン取り込み、細胞内グルタチオン(GSH)蓄積とそれによる細胞内ROS抵抗性による、薬剤耐性機序の寄与について、胃がん化学療法の主翼を担う2剤で明らかにすることができた。S-1,つまりその代謝物である5-FUの耐性機序は本トランスポーター増強の寄与度は高いものの、trastuzumabの場合は、必ずしも本系だけではないという結果が得られてきており、薬剤によりその耐性を担う細胞形質が若干異なると考えられた。つまり、trastuzumabの場合は、細胞内GSH濃度の増強だけでなく、ミトコンドリアに存在する抗酸化酵素MnSOD量もCD44v9-NCI-N87で、NCI-N87に比し上昇しており、HER2陽性細胞のtrastuzumab耐性機序にはxCTに依存度の高いGSH増強によるROS抵抗性ばかりでなく、MnSOD誘導によるROS抵抗性も獲得することで薬剤耐性を発揮している可能性が考えられた。このため、本機序の詳細をin vitroでさらに明らかにした上で、in vivoあるいはPET/CT診断検査への応用が必要であると考えられ、この段階の基礎的検討を行う必要が生じた。

Strategy for Future Research Activity

HER2陽性肝転移胃高分化型腺癌細胞株NCI-N87ではtrastuzumab用量依存的に細胞生存率は低下し、細胞内ROS蓄積を認めたものの、CD44v9-NCI-N87ではtrastuzumab投与でも生存率は低下せず、ROS蓄積亢進も認めなかったことから、HER2発現細胞でも、CD44v9発現によりtrastuzumab耐性を獲得することが示されたが、この機序はxCT依存性のGSH蓄積性ばかりでなく、ミトコンドリア内でのMnSOD誘導も重要であることがわかったため、まずは、この機序を詳細に検討する。これらの知見の確認ができた上で、in vitro での細胞標識実験を実施し、さらにNOGマウスを用いた担がん動物でのがん腫の悪性化、さらには標識細胞の検出技術に応用し、CD44v9陽性胃がん幹細胞のアミノ酸代謝を標的した新規診断法開発の基盤構築を実施する予定である。

  • Research Products

    (51 results)

All 2014 2013 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results,  Open Access: 5 results) Presentation (26 results) (of which Invited: 9 results) Book (2 results)

  • [Journal Article] Greater loss of productivity among Japanese workers with gastroesophageal reflux disease (GERD) symptoms that persist vs resolve on medical therapy.2014

    • Author(s)
      Suzuki, H., Matsuzaki, J., Masaoka, T., Inadomi, J.M.
    • Journal Title

      Neurogastroenterol. Motil.

      Volume: 26 Pages: 764-771

    • DOI

      10.1111/nmo.12319.

    • Peer Reviewed / Open Access
  • [Journal Article] Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease.2014

    • Author(s)
      Tanaka, K., Kurotsu, S., Asano, T., Yamakawa, N., Kobayashi, D., Yamashita, Y., Yamazaki, H., Ishihara, T., Watanabe, H., Maruyama, T., Suzuki, H., Mizushima, T.
    • Journal Title

      Sci. Rep.

      Volume: 4 Pages: 4510

    • DOI

      10.1038/srep04510.

    • Peer Reviewed / Open Access
  • [Journal Article] A questionnaire-based survey on the diagnosis and management of inflammatory bowel disease in East Asian countries in 2012.2014

    • Author(s)
      Hida, N., Nakamura, S., Hahm, K-B., Sollano, J.D., Zhu, Q., Rani, A.A., Syam, A.F., Kachintorn, U., Ueno, F., Joh, T., Naito, Y., Suzuki, H., Takahashi, S., Fukudo, S., Fujiwara, Y., Kinoshita, Y., Uchiyama, K., Yamaguchi, Y., Yoshida, A., Arakawa, T., Matsumoto, T., The IGICS Study Group.
    • Journal Title

      Digestion

      Volume: 89 Pages: 88-103

    • DOI

      10.1159/000356706.

    • Peer Reviewed / Open Access
  • [Journal Article] Does bile reflux influence the progression of Barrett's esophagus to adenocarcinoma?2014

    • Author(s)
      Masaoka, T., Suzuki, H.
    • Journal Title

      J. Neurogastroenterol. Motil.

      Volume: 20 Pages: 124-126

    • DOI

      10.5056/jnm.2014.20.1.124.

    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNAs in Barrett’s esophagus: Future prospects.2014

    • Author(s)
      Matsuzaki, J., Suzuki, H.
    • Journal Title

      Front. Genet.

      Volume: 5 Pages: 69

    • DOI

      10.3389/fgene.2014.00069.

    • Peer Reviewed / Open Access
  • [Journal Article] New pharmaceutical treatment of gastric MALT lymphoma: anti-angiogenesis treatment using VEGF receptor antibodies and celecoxib.2014

    • Author(s)
      Nakamura, M., Takahashi, T., Matsui, H., Takahashi, S., Murayama, SY.,Suzuki, H., Tsuchimoto, K.
    • Journal Title

      Curr. Pharm. Des.

      Volume: 20(7) Pages: 1097-103

    • Peer Reviewed
  • [Journal Article] Effect of ursodeoxycholic acid and endoscopic sphincterotomy in long-term stenting for common bile duct stones.2013

    • Author(s)
      Nishizawa, T., Suzuki, H., Takahashi, M., Kaneko, H., Suzuki, M., Hibi, T.
    • Journal Title

      J. Gastroenterol. Hepatol.

      Volume: 28(1) Pages: 63-67

    • DOI

      10.1111/jgh.12012.

    • Peer Reviewed
  • [Journal Article] Helicobacter pylori infection in functional dyspepsia.2013

    • Author(s)
      Suzuki, H., Moayyedi, P.
    • Journal Title

      Nat Rev. Gastroenterol Hepatol

      Volume: 10(3) Pages: 168-174

    • DOI

      10.1038/nrgastro.2013.9.

    • Peer Reviewed
  • [Journal Article] Improvement of reflux symptom related quality of life after Helicobacter pylori eradication therapy.2013

    • Author(s)
      Hirata, K., Suzuki, H., Matsuzaki, J., Masaoka, M., Saito, Y., Nishizawa, T., Iwasaki, E., Fukuhara, S., Okada, S., Hibi, T.
    • Journal Title

      J. Clin. Biochem. Nutr.

      Volume: 52(2) Pages: 172-178

    • DOI

      10.3164/jcbn.12-107.

    • Peer Reviewed
  • [Journal Article] Biliary findings assist in predicting enlargement of intraductal papillary mucinous neoplasms of the pancreas.2013

    • Author(s)
      Matsuzaki, J., Suzuki, H., Okuda, S., Tanimoto, A., Asakura, K., Fukuhara, S., Okada, S., Hirata, K., Mori, H., Masaoka, T., Higuchi, H., Hozawa, S., Kuribayashi, S., Takebayashi, T., Hibi, T.
    • Journal Title

      Clin. Gastroenterol. Hepatol.

      Volume: 11(5) Pages: 548-554

    • DOI

      10.1016/j.cgh.2012.11.027.

    • Peer Reviewed
  • [Journal Article] Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain- containing m-Numb protein expression in regenerating gastric mucosa.2013

    • Author(s)
      Takahashi, T., Suzuki, H., Imai, T, Shibata, S., Tabuchi, Y., Tsuchimoto, K., Okano, H., Hibi, T.
    • Journal Title

      PLoS One

      Volume: 8(1) Pages: e53540

    • DOI

      10.1371/journal.pone.0053540.

    • Peer Reviewed
  • [Journal Article] Impaired heme oxygenase-1 induction in the gastric antrum induces disruption of the interstitial cells of Cajal network in a rat model of streptozotocin-induced diabetes.2013

    • Author(s)
      Mogami, S., Suzuki, H., Tsugawa, H., Fukuhara, S., Hibi, T.
    • Journal Title

      Neurogastroenterol. Motil.

      Volume: 25(7) Pages: 609-e465

    • DOI

      10.1111/nmo.12122.

    • Peer Reviewed
  • [Journal Article] Validation of the GerdQ questionnaire for the management of gastroesophageal reflux disease in Japan.2013

    • Author(s)
      Suzuki, H., Matsuzaki, J., Okada, S., Fukuhara, S., Hirata, K., Hibi, T.
    • Journal Title

      ueg journal

      Volume: 1(3) Pages: 175-183

    • DOI

      10.1177/2050640613485238

    • Peer Reviewed
  • [Journal Article] Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier.2013

    • Author(s)
      Mizuno, S., Yamagishi, Y., Ebinuma, H., Nakamoto, N., Katahira, M., Sasaki, A., Sakamoto, M., Suzuki, H., Kanai, T., Hibi, T.
    • Journal Title

      Clin. J. Gastroenterol.

      Volume: 6(2) Pages: 188-192

    • Peer Reviewed
  • [Journal Article] The role of microRNA in gastric malignancy.2013

    • Author(s)
      Nishizawa, T., Suzuki, H.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 14(5) Pages: 9487-96

    • DOI

      10.3390/ijms14059487.

    • Peer Reviewed
  • [Journal Article] Delay of second-line eradication therapy for H. pylori can increase eradication failure.2013

    • Author(s)
      Nishizawa, T., Suzuki, H., Takahashi, M., Suzuki, M., Hibi, T.
    • Journal Title

      J. Gastroenterol. Hepatol.

      Volume: 28(10) Pages: 1608-10

    • DOI

      10.1111/jgh.12281.

    • Peer Reviewed
  • [Journal Article] Trends of second-line eradication therapy for Helicobacter pylori in Japan: A Multicenter Study in the Tokyo Metropolitan Area.2013

    • Author(s)
      Asaoka, D., Nagahara, A., Matsuhisa, T., Takahashi, S., Tokunaga, K., Kawai, T., Suzuki, H., Suzuki, M., Nishizawa, T., Kurihara, N., Ito, M., Sasaki, H., Omata, F., Mizuno, S., Torii, A., Ohkusa, T., Mine, T., Sakaki, N.
    • Journal Title

      Helicobacter

      Volume: 18(6) Pages: 468-72

    • DOI

      10.1111/hel.12063.

    • Peer Reviewed
  • [Journal Article] CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.2013

    • Author(s)
      Hirata, K., Suzuki, H., Imaeda, H., Matsuzaki, J., Tsugawa, H., Nagano, O., Asakura, K., Saya, H., Hibi, T.
    • Journal Title

      Br. J. Cancer.

      Volume: 109(2) Pages: 379-86

    • DOI

      10.1038/bjc.2013.314.

    • Peer Reviewed
  • [Journal Article] Do we need to eradicate H. pylori in patients with GORD?2013

    • Author(s)
      Masaoka, T., Suzuki, H.
    • Journal Title

      ueg journal

      Volume: 1(4) Pages: 223-225

    • DOI

      10.1177/2050640613497713

    • Peer Reviewed
  • [Journal Article] Bile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis.2013

    • Author(s)
      Matsuzaki, J., Suzuki, H., Tsugawa, H., Watanabe, M., Hossain, S., Arai, E., Saito, Y., Sekine, S., Akaike, T., Kanai, Y., Mukaisho, K.I., Auwerx, J., Hibi, T.
    • Journal Title

      Gastroenterology

      Volume: 145(6) Pages: 1300-11

    • DOI

      10.1053/j.gastro.2013.08.008.

    • Peer Reviewed
  • [Journal Article] Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease.2013

    • Author(s)
      Tanaka, K., Ishihara, T., Sugizaki, T., Kobayashi D., Yamashita, Y., Tahara, K., Yamakawa, N., Iijima, K., Mogushi, K., Tanaka, H., Sato, K.,Suzuki, H., Mizushima, T.
    • Journal Title

      Nature Commun.

      Volume: 4 Pages: 2686

    • DOI

      10.1038/ncomms3686.

    • Peer Reviewed
  • [Journal Article] Effect of lansoprazole on the epigastric symptoms of functional dyspepsia (ELF study) : a multicenter, prospective, randomized, double-blind, placebo-controlled clinical trial.2013

    • Author(s)
      Suzuki, H., Kusunoki, H., Kamiya, T., Futagami, S., Yamaguchi, Y., Nishizawa, T., Iwasaki, E., Matsuzaki, J., Takahashi, S., Sakamoto, C., Haruma, K., Joh, T., Asakura, K., Hibi, T.
    • Journal Title

      ueg journal

      Volume: 1(6) Pages: 445-452

    • DOI

      10.1177/2050640613510904

    • Peer Reviewed
  • [Journal Article] Endoscopic microvascular patterns of gastrointestinal cancer.2013

    • Author(s)
      Nishizawa, T., Suzuki, H.
    • Journal Title

      Microvasc. Rev. Commun.

      Volume: 6(1) Pages: 9-12

    • Peer Reviewed
  • [Presentation] Bile Acids Enhance Oncogenic miR-221/222 in the Transformation From Barrett’s Esphagus to Adenocarcinoma.2013

    • Author(s)
      Matsuzaki, J., Suzuki, H., Tsugawa, H., Saito, Y., Hossain, S., Arai, E., Sekine, S., Kanai, Y., Watanabe, M., Akaike, T., Mukaisho, K., Auwerx, J., Hibi, Y.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando
    • Year and Date
      20130519-20130523
  • [Presentation] Expression of CD44 Variant 9 Contributes to 5-Fluorouracil Resistance in Gastric Cancer Trough Anti-Oxidative Stress Mechanism.

    • Author(s)
      Okada, S., Suzuki, H., Masaoka, T., Tsugawa, H., Matsuzaki, J., Fukuhara, S., Hirata, K., Mori, H., Saya, H., Hibi, T.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando
  • [Presentation] The Loss of Work Productivity Associated with Gastroesophageal Reflux Disease (GERD) in a Japanese Working Population

    • Author(s)
      Suzuki, H., Matsuzaki, J., Masaoka, T., Okada, S., Inadomi, J., Hibi, T.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando
  • [Presentation] Application of 13C-acetic acid breath test for animals with impaired gastric motility

    • Author(s)
      Fukuhara, S., Suzuki, H., Masaoka, T., Suemasu, S., Matsuzaki, J., Tsugawa, H., Okada, S., Hirata, K., Mori, H., Saito, Y., Mizushima, T., Hibi, T.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlamdo
  • [Presentation] Role of microRNA and cancer stem cells in gastric carcinogenesis

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      The XXVIth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Madrid
    • Invited
  • [Presentation] Analysis of CagA serotypes with Helicobacter pylori multiplex serology

    • Author(s)
      Michel, A., Wang, S., Zhang, W., Kist, M., Figueroa, G., Dondog, B., Suzuki, H., Pawlita, M.
    • Organizer
      The XXVIth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Madrid
  • [Presentation] Trends of second-line eradication therapy for Helicobacter pylori in Japan: A Multicenter Study in the Tokyo Metropolitan Area

    • Author(s)
      Asaoka, D., Nagahara, A., Matsuhisa, T., Takahashi, S., Tokunaga, K., Kawai, T., Kawakami, K., Suzuki, H., Suzuki, M., Nishizawa, T., Kurihara, N., Ito, M., Sasaki, H., Omata, F., Mizuno, S., Torii, A., Ohkusa, T., Mine, T., Sakaki, N.
    • Organizer
      The XXVIth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Madrid
  • [Presentation] Influence of Helicobacter pylori on gastric carcinogenesis and functional disturbance

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      The International Joint Meeting of IBS Conference and Rome Committee in Tokyo
    • Place of Presentation
      Tokyo
    • Invited
  • [Presentation] Autophagy causing CagA degradation is triggered by cytoplasmic accumulation of low-density lipoprotein receptor-related protein-1 (LRP1) in gastric epithelial cells infected with H. pylori.

    • Author(s)
      Tsugawa, H., Matsuzaki, J., Okada, S., Fukuhara, S., Mori, H., Masaoka, T., Sato, A., Saya, H., Hatakayama, M., Hirayama, T., Suzuki, H.
    • Organizer
      UEGW2013
    • Place of Presentation
      Berlin
  • [Presentation] H. pylori eradication for cancer prevention in clinical practice

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      UEGW2013
    • Place of Presentation
      Berlin
    • Invited
  • [Presentation] Involvement of stemness factors in the intestinal transdifferentiation of gastric epithelial cells

    • Author(s)
      Fujii, Y., Suzuki, H., Aburatani, H., Hatakayama, M.
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      Urayasu
  • [Presentation] CD44v9 play a role to anti-tumor effect against human gastric cancer by trastuzumab.

    • Author(s)
      Mori, H., Suzuki, H., Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Masaoka, T., Kanai, T., Saya, H.
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      Urayasu
  • [Presentation] Escaped autophagy of H. pylori-derived oncoprotein CagA in gastric cancer stem-like cells

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      Urayasu
    • Invited
  • [Presentation] High-level resistance to metronidazole for Helicobacter pylori is more prevalent in patients with postprandial distress syndrome.

    • Author(s)
      Matsuzaki, J., Suzuki, H., Mori, H., Tsugawa, H., Masaoka, T., Miyoshi, S., Fukuhara, S., Kanai, T.
    • Organizer
      The 4th Asian Pacific Single Topic Conference
    • Place of Presentation
      Tagaytay
    • Invited
  • [Presentation] Impairment of apolipoprotein E evokes delayed gastric emptying through nitrergic dysfunction.

    • Author(s)
      Fukuhara, S., Suzuki, H., Masaoka, T., Tsugawa, H., Okada, S., Mori, H., Hirata, K., Matsuzaki, J., Iwasaki, E., Mizushima, T., Suzuki, M.
    • Organizer
      The 7th International Gastrointestinal Consensus Symposium (IGICS)
    • Place of Presentation
      Fukushima
  • [Presentation] Expression of CD44 variant 9 contributes to 5-fluorouracil resistance in gastric cancer through anti-oxidative stress mechanism

    • Author(s)
      Miyoshi, S., Suzuki, H., Tsugawa, H., Masaoka, T., Matsuzaki, J., Fukuhara, S., Hirata, K., Mori, H., Kanani, T., Saya, H.
    • Organizer
      17th Biennial Meeting of Society for Free Radical Research International (SFRRI2014)
    • Place of Presentation
      Kyoto
  • [Presentation] The role of reactive oxygen species (ROS) in gastric carcinogenesis evoked by H. pylori infection

    • Author(s)
      Tsugawa, H., Suzuki, H.
    • Organizer
      17th Biennial Meeting of Society for Free Radical Research International (SFRRI2014)
    • Place of Presentation
      Kyoto
  • [Presentation] Helicobacter pylori感染症 -酸化ストレス関連性病態機序-

    • Author(s)
      鈴木秀和
    • Organizer
      第66回日本酸化ストレス学会学術集会
    • Place of Presentation
      名古屋
    • Invited
  • [Presentation] H. pyloriがん蛋白質CagAのCD44v9発現がん幹細胞特異的蓄積メカニズムの発見

    • Author(s)
      津川仁、鈴木秀和、佐谷秀行、松崎潤太郎、平田賢郎、福原誠一郎、岡田佐和子、正岡建洋、畠山昌則、平山壽哉、日比紀文
    • Organizer
      第19回日本ヘリコバクター学会学術集会
    • Place of Presentation
      長崎
  • [Presentation] 国民総除菌で胃がんを撲滅する。

    • Author(s)
      鈴木秀和
    • Organizer
      第19回日本ヘリコバクター学会学術集会
    • Place of Presentation
      長崎
    • Invited
  • [Presentation] ピロリ菌感染時の胃発がんリスクを規定するオートファジーの発現制御システム

    • Author(s)
      津川仁、鈴木秀和
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      横浜
  • [Presentation] 食道腺がんにおけるmiR-221/222の発現動態と抗マイクロRNA治療標的としての有用性

    • Author(s)
      松崎潤太郎、鈴木秀和、日比紀文
    • Organizer
      第21回日本消化器病関連学会週間(JDDW2013)
    • Place of Presentation
      東京
  • [Presentation] H. pylori感染症とFD

    • Author(s)
      鈴木秀和
    • Organizer
      第15回日本神経消化器病学会
    • Place of Presentation
      出雲
    • Invited
  • [Presentation] ピロリ菌がん蛋白質CagAを排除する宿主応答

    • Author(s)
      津川仁、鈴木秀和
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
  • [Presentation] ピロリ菌感染症の診療を巡る最新知識

    • Author(s)
      鈴木秀和
    • Organizer
      第42回日本総合健診医学会大会
    • Place of Presentation
      東京
    • Invited
  • [Presentation] がん蛋白質CagAの細胞内安定性を規定するautophagyの発現制御システム

    • Author(s)
      津川仁、鈴木秀和、森英毅、福原誠一郎、岡田佐和子、正岡建洋、佐藤聡、井本正哉、金井隆典
    • Organizer
      第10回日本消化管学会総会学術総会
    • Place of Presentation
      福島
  • [Book] eBook: Helicobacter pylori - A Worldwide Perspective 20142014

    • Author(s)
      Suzuki, H., Nishizawa, T., Hibi, T.
    • Total Pages
      -
    • Publisher
      Bentham Science Publishers
  • [Book] CANCER: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS2014

    • Author(s)
      Suzuki, H., Nishizawa, T.
    • Total Pages
      pp33-40
    • Publisher
      Academic Press

URL: 

Published: 2015-05-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi