Analysis of the functions of anti-apoptotic molecule, Anamorsin -the roles in hematopoiesis and cellular iron metabolism-

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293220
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Osaka University
• Principal Investigator: KANAKURA Yuzuru 大阪大学, 医学(系)研究科(研究院), 教授 (20177489)
• Co-Investigator(Kenkyū-buntansha): SHIBAYAMA Hirohiko 大阪大学, 大学院医学系研究科, 講師 (60346202) ; ORITANI Kenji 大阪大学, 大学院医学系研究科, 准教授 (70324762) ; MIZUKI Masao 大阪大学, 医学部附属病院, 准教授 (80283761)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アナモルシン / コンディショナルノックアウトマウス / 造血幹細胞 / 鉄・硫黄クラスター / アポトーシス

Outline of Final Research Achievements

In this study, we have generated Anamorsin (AM) conditional knock-out mice, which delete AM in the specific organ by mating the organ-specific Cre recombinase transgenic mice, and analyzed the functions of AM in the specific organ. The defect of AM in the embryonic hematopoietic stem cells leads to anemia and embryonic lethality, which are identical with the phenotypes of AM deficient mice. The induction of AM deficiency in the hematopoietic cells in the adult mice lead to the increase of apoptosis in the hematopoietic stem cells. From these data, it was shown that AM plays important roles in both of the embryonic and adult hematopoietic stem cells.

Free Research Field

血液内科