Clarification of the mechanism of the chronicity of allergic diseases and establishment of the thrapeutic strategy against it

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293224
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Saga University
• Principal Investigator: Izuhara Kenji 佐賀大学, 医学部, 教授 (00270463)
• Co-Investigator(Kenkyū-buntansha): ARIMA Kazuhiko 佐賀大学, 医学部, 准教授 (60336112) ; SUZUKI Shoichi 佐賀大学, 医学部, 助教 (40253695) ; OHTA Shoichiro 佐賀大学, 医学部, 助教 (20346886) ; OGAWA Masahiro 佐賀大学, 医学部, 助教 (90599317) ; NUNOMURA Satoshi 佐賀大学, 医学部, 助教 (70424728) ; YAMAMOTO Kenichi 佐賀大学, 医学部, 研究員 (00711798) ; INAMITSU Masako 佐賀大学, 医学部, 研究員 (10711814) ; NANRI Yasuhiro 佐賀大学, 医学部, 研究員 (00382218)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アレルギー / アトピー性皮膚炎 / アレルギー性結膜炎 / サイトカイン

Outline of Final Research Achievements

Although it is known that type 2 immunity is the main body of allergic inflammation, the detailed mechanism of allergic inflammation evoked by IL-4 or IL-13, signature type 2 cytokines is unclear. We have focused on periostin, an IL-4- or IL-13-inducible product. We, in this study, found that periostin and IL-1alpha produced in fibroblasts and keratinocytes, respectively, co-operatively act on fibroblasts inducing production of IL-6. Moreover, we found that high concentration of periostin is detected in tears of allergic conjunctivitis patients correlated with their clinical severities, suggesting the usefulness of measurement of tear periostin for treatment of allergic conjunctivitis.

Free Research Field

膠原病・アレルギー内科学