Transplantation of adipose tissue derived multilineage progenitor cells via portal vein improved serum levels of mucopolysaccharidosis model mice.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293229
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Osaka University
• Principal Investigator: Matsuyama Akifumi 大阪大学, 国際医工情報センター, 招へい教授 (10423170)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 再生医療 / ムコ多糖症 / ライソゾーム病 / 遺伝子疾患

Outline of Final Research Achievements

The mechanism of this study is in vivo engrafted reprogrammed-hepatocyte from adipse tisse derived multilinage progenitor cell, so called ‘ADMPC’ sustained secrete and supplied lysosomal hydrolase deficient in mucopolysaccharidosis to the whole body.Via the portal vein administration of ADMPC, β-galactosidase that are deficient GM1- gangliosidosis mouse, which is a mucopolysaccharidosis model animal had expressed in the blood, and the effect has been revealed that long-lasting. ADMPC have been induced to differentiate into hepatocytes in the liver, so we proposed the new concept of the "in situ reprogramming". The concept is defferent from "Reprogramming", reprogrammed terminal differentiated cell to pluripotent cells and "direct reprogramming", to differentiate directly to the target cells in vitro gene transfer, so far. We are going to deploy this as in situ stem cell therapy to the treatment.

Free Research Field

再生医療