2016 Fiscal Year Final Research Report
Molecular Mechanisms of atherosclerotic remodeling in childhood
| Project/Area Number |
25293236
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
市川 泰広 横浜市立大学, 医学部, 助教 (10555121)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIMOTO Yukihiko 熊本大学, 生命科学研究部, 教授 (80243038)
NISHIHARA Hiroshi 北海道大学, 医学研究科, 特任准教授 (50322805)
ARAKAWA Noriaki 横浜市立大学, 生命ナノシステム科学研究科, 助教 (60398394)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 動脈硬化 / 小児 / 内膜肥厚 / リモデリング / 冠動脈 |
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| Outline of Final Research Achievements |
The process of progression of atherosclerosis during childhood and its molecular mechanisms are not fully understood. We aimed to examine the developmental changes of atherosclerosis using vascular tissue samples ranging in age from 0 to 71 years old. In human coronary arterial smooth muscle cells, prostaglandin E receptor EP4 was highly expressed among EP receptors. Physiological intimal thickening was observed from newborn infants. We analyzed ApoE-/- EP4+/+ and ApoE-/- EP4+/- mice and found that EP4 deficiency inhibited atherosclerotic plaque formation. These data suggested that EP4 contributes to progression of atherosclerotic remodeling from childhood.
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| Free Research Field |
小児循環器
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