Development of a multipurpose microreactor system for preparation of 18F-labeled probes

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293257
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: Iwata Ren 東北大学, サイクロトロン・ラジオアイソトープセンター, 名誉教授 (60143038)
• Co-Investigator(Kenkyū-buntansha): FURUMOTO SHOZO 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00375198) ; TAKAHASHI KAZUHIRO 慶応義塾大学, 医学部, 特任准教授 (20370257)
• Co-Investigator(Renkei-kenkyūsha): SAIKI HIDEKAZU 島津製作所, 分析計測事業部, 主任 (70466382)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: マイクロリアクター / 標識合成 / 分子イメージング / 自動合成 / 標識プローブ / フッ素-18

Outline of Final Research Achievements

A new microreactor system using electrochemically concentrated [18F]fluoride was developed for preparation of many useful 18F-labeled probes. Novel approaches were evaluated with re-concentration of a reaction solvent in an evaporation flow chip between microfluidic reactions and on-chip 18F-labeling in an electrochemical flow cell where [18F]fluoride was trapped from a flowing water and then released in an aprotic solvent. However, the results showed they were both not promising methods employed for microfluidic reaction. On the other hand, solid phase extraction was successfully adapted to the present system. As a typical demonstration, a hypoxic cell marker [18F]FRP170 was efficiently and rapidly prepared with high qualities as an injection.

Free Research Field

放射性医薬品学