Elucidation of mechanism for the occurence of vertigo attacks in Meniere's disease by advanced diagnositic imaging techniques

2016 Fiscal Year Annual Research Report

• Project/Area Number: 25293263
• Research Institution: Nagoya University
• Principal Investigator: 長縄 慎二 名古屋大学, 医学(系)研究科(研究院), 教授 (50242863)
• Co-Investigator(Kenkyū-buntansha): 山崎 雅弘 名古屋大学, 医学部附属病院, 病院助教 (40595526) ; 鈴木 耕次郎 愛知医科大学, 医学部, 准教授 (60378148) ; 岩野 信吾 名古屋大学, 医学(系)研究科(研究院), 准教授 (90335034)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: メニエール病 / 内リンパ水腫 / MRI

Outline of Annual Research Achievements

メニエール病はめまい発作、難聴、耳閉感を症候の主体とする良性疾患であるが、現実には、非常に多くの患者の社会的生活を奪う反面、決定的な診断法と治療法が未だにない難病である。2007年、ようやく我々が世界ではじめてメニエール病患者における内リンパ水腫を鼓室内Gd-DTPA注入後のMRIで画像化することに成功した。我々は世界に先駆けて、MRIによるメニエール病の内リンパ水腫検出法と評価法の開発を進め客観的診断法の確立をしてきた。
めまいを伴うメニエール病患者では必ず球形嚢に水腫があることがわかった。また片頭痛や迷路奇形などの他疾患がある場合の内リンパ水腫への影響と評価方法の開発と検討を行った。さらにメニエール病と関連の深い、突発性難聴でめまいを伴うものの取得済データ解析、耳硬化症症例における取得済データの解析をおこなって、臨床的にも純粋なメニエール病の辺縁疾患における水腫の解析をおこなって、病態解明につなげた。
1700例以上の経験から、メニエール病患者では必ず水腫があるが、水腫があっても必ずしも症状のない患者が存在することがわかってきたが内リンパ水腫がめまい発作を起こすメカニズムは依然、謎であり、その解明なしには根本治療法開発も困難である。また最終年度には、健常者における至適撮像時間のさらなる検討をおこなった。延長した年度には、メニエール病と関連の深い、突発性難聴でめまいを伴うものの取得済データ解析の継続、耳硬化症症例における取得済データの解析の継続をおこない、臨床的にメニエール病の辺縁疾患における水腫の解析、病態解明につなげた。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Do gadolinium-based contrast agents affect the 18F-FDG PET/CT uptake in the dentate nucleus and the globus pallidus? (2017)
  • Author(s): Shinji Naganawa
  • Journal Title: J Nucl Med Technol. Volume: 印刷中 Pages: -
  • DOI: 10.2967/jnmt.116.187591.
  • Peer Reviewed
• [Journal Article] Gd-based Contrast Enhancement of the Perivascular Spaces in the Basal Ganglia. (2017)
  • Author(s): Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka
  • Journal Title: Magn Reson Med Sci. Volume: 16(1) Pages: 61-65
  • DOI: 10.2463/mrms.mp.2016-0039.
  • Peer Reviewed / Open Access
• [Journal Article] Lack of Contrast Enhancement in a Giant Perivascular Space of the Basal Ganglion on Delayed FLAIR Images: Implications for the Glymphatic System. (2017)
  • Author(s): Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka
  • Journal Title: Magn Reson Med Sci. Volume: 印刷中 Pages: -
  • DOI: 10.2463/mrms.ci.2016-0114.
  • Peer Reviewed / Open Access
• [Journal Article] Emerging neuroradiological topics in journals from related societies. (2017)
  • Author(s): Yukunori Korogi, Shinji Naganawa
  • Journal Title: Jpn. J Radiol. Volume: 35（1） Pages: 1-2
  • DOI: 10.1007/s11604-016-0600-0.
  • Peer Reviewed / Open Access
• [Journal Article] Endolymphatic hydrops in patients with unilateral and bilateral Meniere's disease. (2017)
  • Author(s): Kyoko Morimoto, Tadao Yoshida, Saiko Sugiura, Masahiro Kato, Ken Kato, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone
  • Journal Title: Acta Otolaryngol. Volume: 137(1) Pages: 23-28
  • DOI: 10.1080/00016489.2016.1217042
  • Peer Reviewed / Open Access
• [Journal Article] Magnetic resonance imaging evaluation of endolymphatic hydrops andpost-operative findings in cases with otosclerosis. (2017)
  • Author(s): Michihiko Sone, Tadao Yoshida, Satofumi Sugimoto, Kyoko Morimoto, Yuriko Okazaki, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima
  • Journal Title: Acta Otolaryngol. Volume: 137(3) Pages: 242-245
  • DOI: 10.1080/00016489.2016.1232862.
  • Peer Reviewed / Open Access
• [Journal Article] Clinical outcome of definitive radiation therapy for superficial esophageal cancer. (2017)
  • Author(s): Yutaro Koide, Takeshi Kodaira, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Makoto Itoh, Tetsuya Abe, Kei Muro, Masahiro Tajika, Yasumasa Niwa, Yoshiyuki Itoh , Shinji Naganawa
  • Journal Title: Jpn J Clin Oncol Volume: - Pages: 1-8
  • DOI: 10.1093/jjco/hyx021.
  • Peer Reviewed / Open Access
• [Journal Article] Structure of the Medullary Veins of the Cerebral Hemisphere and Related Disorders. (2017)
  • Author(s): Toshiaki Taoka, Akio Fukuisumi, Toshiteru Miyasaka, Hisashi Kawai, Toshiki Nakane, Kimihiko Kichikawa, Shinji Naganawa
  • Journal Title: Radiographics. Volume: 37(1) Pages: 281-297
  • DOI: 10.1148/rg.2017160061.
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases. (2017)
  • Author(s): Toshiaki Taoka, Yoshitaka Masutani, Hisashi Kawai, Toshiki Nakane, Kiwamu Matsuoka, Fumihiko Yasuno, Toshifumi Kishimoto, Shinji Naganawa
  • Journal Title: Jpn J Radiol. Volume: 35(4) Pages: 172-178
  • DOI: 10.1007/s11604-017-0617-z
  • Peer Reviewed / Open Access
• [Journal Article] Imaging of the endolymphatic space in patients with Meniere's disease. (2017)
  • Author(s): Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Hironao Otake, Masahiro Yamazaki, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone
  • Journal Title: Auris Nasus Larynx. Volume: 17(30) Pages: 142-147
  • DOI: 10.1016/j.anl.2017.02.002.
  • Peer Reviewed / Open Access
• [Journal Article] CSF Pulsation Artifacts on ADC Maps Obtained with Readout-segmented EPI. (2016)
  • Author(s): Toshio Ohashi, Shinji Naganawa, Mai Kanou, Mitsuru Ikeda
  • Journal Title: Magn Reson Med Sci. Volume: 印刷中 Pages: -
  • DOI: 10.2463/mrms.mp.2016-0031
  • Peer Reviewed / Open Access
• [Journal Article] Meniere’s disease (2016)
  • Author(s): Tsutomu Nakashima, Ilmari Pyykko, Megan A. Arroll, Margaretha L. Casselbrant, Carol A. Foster, Nauman F. Manzoor, Cliff A. Megerian, Shinji Naganawa,Ho Young
  • Journal Title: Nat Rev Dis Primers. Volume: 2 Pages: 16028
  • DOI: 10.1038/nrdp.2016.28.
  • Peer Reviewed
• [Journal Article] Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum. (2016)
  • Author(s): Michihito Masuda, Joe Senda, Hirohisa Watanabe, Bagarinao Epifanio, Yasuhiro Tanaka, Kazunori Imai, Yuchi Riku, Yuanzhe Li, Ryoichi Nakamura, Mizuki Ito, Shinsuke Ishigaki, Naoki Atsuta, Haruki Koike, Katsuno Masahisa, Nobutaka Hattori, Shinji Naganawa, Gen Sobue
  • Journal Title: Amyotroph Lateral Scler Frontotemporal Degener. Volume: 17(7) Pages: 571-579
  • DOI: 10.1080/21678421.2016.1211151
  • Peer Reviewed / Open Access
• [Journal Article] Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue (2016)
  • Author(s): Gregor Jost, Thomas Frenzel, Jessica Lohrke, Diana Constanze Lenhard, Shinji Naganawa, Hubertus Pietsch
  • Journal Title: Eur Radiol. Volume: - Pages: -
  • DOI: 10.1007/s00330-016-4654-2
  • Peer Reviewed / Open Access
• [Journal Article] Active brain changes after initiating fingolimod therapy in multiple sclerosis patients using individual voxel-based analyses for diffusion tensor imaging. (2016)
  • Author(s): Joe Senda, Hirohisa Watanabe, Kuniyuki Endo, Keizo Yasui, Yasuhiro Hawsegawa, Noritaka Yoneyama, Takashi Tsuboi, Kazuhiro Hara, Mizuki Ito, Naoki Atsuta, Bagarinao Epifanio Jr, Masahisa Katsuno, Shinji Naganawa, Gen Sobue
  • Journal Title: Nagoya J Med Sci. Volume: 78(4) Pages: 455-463
  • DOI: 10.18999/nagjms.78.4.455.
  • Peer Reviewed / Open Access
• [Journal Article] Late Rectal Toxicity from Image-guided Intensity Modulated Radiotherapy for Prostate Cancer. (2016)
  • Author(s): Sayo Maki, Yoshiyuki Itoh, Seiji Kubota, Tohru Okada, Rie Nakahara, Junji Ito, Mariko Kawamura, Takeshi Kamomae, Shinji Naganawa, Yasushi Yoshino, Momokazu Gotoh, Mitsuru Ikeda
  • Journal Title: Anticancer Res. Volume: 36(6) Pages: 2967-2974
  • Peer Reviewed / Open Access
• [Journal Article] A multicenter survey of stage T1 glottic cancer treated with radiotherapy delivered in 2.25-Gy fractions in clinical practice: An initial 5-year analysis. (2016)
  • Author(s): Yoshiyuki Itoh, Seiji Kubota, Mariko Kawamura, Yoshihito Nomoto, Takayuki Murao, Kouji Yamakawa, Shunichi Ishihara, Naoki Hirasawa, Akiko Asano, Shigeo Yanagawa, Shinji Naganawa
  • Journal Title: Nagoya J. Med. Sci. Volume: 78(4) Pages: 399-406
  • DOI: 10.18999/nagjms.78.4.399.
  • Peer Reviewed / Open Access
• [Journal Article] Diffusion tensor studies and voxel-based morphometry of the temporal lobe to determine the cognitive prognosis in cases of Alzheimer’s disease and mild cognitive impairment: Do white matter changes precede gray matter changes? (2016)
  • Author(s): Toshiaki Taoka,corresponding author Fumihiko Yasuno, Masayuki Morikawa, Makoto Inoue, Kuniaki Kiuchi, Soichiro Kitamura, Kiwamu Matsuoka, Toshifumi Kishimoto, Kimihiko Kichikawa, Shinji Naganawa
  • Journal Title: SpringerPlus. Volume: 5(1) Pages: 1023
  • DOI: 10.1186/s40064-016-2692-5.
  • Peer Reviewed / Open Access
• [Journal Article] Application of histogram analysis for the evaluation of vascular permeability in glioma by the K2 parameter obtained with the dynamic susceptibility contrast method: Comparisons with Ktrans obtained with the dynamic contrast enhance method and cerebral blood volume. (2016)
  • Author(s): Toshiaki Taoka, Hisashi Kawai, Toshiki Nakane, Saeka Hori, Tomoko Ochi, Toshiteru Miyasaka, Masahiko Sakamoto, Kimihiko Kichikawa, Shinji Naganawa
  • Journal Title: Magn Reson Imaging. Volume: 34(7) Pages: 896-901
  • DOI: 10.1016/j.mri.2016.04.020
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of locoregional invasiveness of small-sized non-small cell lung cancers by enhanced dual-energy computed tomography. (2016)
  • Author(s): Hironori Shimamoto, Shingo Iwano, Hiroyasu Umakoshi, Koji Kawaguchi, Shinji Naganawa
  • Journal Title: Cancer Imaging. Volume: 16(1) Pages: 18
  • DOI: 10.1186/s40644-016-0077-1.
  • Peer Reviewed / Open Access
• [Journal Article] Contrast-enhanced magnetic resonance pancreatography with gadoteridol by heavily T2-weighted three-dimensional fluid-attenuated inversion recovery: preliminary results in healthy subjects. (2016)
  • Author(s): Kojiro Suzuki, Shinji Naganawa, Naohiro Furuhashi, Masahiro Yamazaki, Hiroshi Ogawa, Hisashi Kawai
  • Journal Title: Nagoya J. Med. Sci. Volume: 78(2) Pages: 175-181
  • Peer Reviewed / Open Access
• [Journal Article] Magnetic resonance imaging of cardiac sarcoidosis: an evaluation of the cardiac segments and layers that exhibit late gadolinium enhancement. (2016)
  • Author(s): Tomohiro Komada, Kojiro Suzuki, Hiroaki Ishiguchim Hisashi Kawai, Takahiro Okumura, Akihiro Hirashikim, Shinji Naganawa
  • Journal Title: Nagoya J. Med. Sci. Volume: 78(4) Pages: 437-446
  • DOI: 10.18999/nagjms.78.4.437.
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of stochastic noise and post-irradiation density growth for reflective-type radiochromic film in therapeutic photon beam dosimetry. (2016)
  • Author(s): Takeshi Kamomae, Masataka Oita, Naoki Hayashi, Motoharu Sasaki, Hideki Aoyama, Hiroshi Oguchi, Mariko Kawamura, Hajime Monzen, Yoshiyuki Itoh, Shiniji Naganawa
  • Journal Title: Phys Med. Volume: 32 Pages: 1314-1320
  • DOI: 10.1016/j.ejmp.2016.07.091
  • Peer Reviewed / Open Access
• [Presentation] Closing Remarks (2017)
  • Author(s): Shinji Naganawa
  • Organizer: 画像診断セミナー in Wien
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2017-03-01 – 2017-03-05
  • Int'l Joint Research
• [Presentation] A comparative analysis of dual-phase dual-energy CT and FDG-PET/CT for the prediction of histopathological. (2017)
  • Author(s): Rintaro Ito, Shingo Iwano, Hironori Shimamoto, Hiroyasu Umakoshi, Shinji Ito, Katsuhiko Kato, Shinji Naganawa
  • Organizer: European Congress of Radiology 2017（ECR)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2017-03-01 – 2017-03-05
  • Int'l Joint Research
• [Presentation] Pattern difference in the area with T2-hyperintensity: comparison between gliomas and edemas by using texture analysis. (2017)
  • Author(s): Hisashi Kawai, Toshiaki Taoka, Toshiki Nakane, Yasuo Sakurai, Shinji Naganawa
  • Organizer: European Congress of Radiology 2017（ECR)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2017-03-01 – 2017-03-05
  • Int'l Joint Research
• [Presentation] The efficacy of percutaneous transhepatic portal vein embolozation using gelatin sponge particles and metallic coils. (2017)
  • Author(s): Tomohiro Komada, Kojiro Suzuki, Masaya Matsushima, Yoshine Mori, Ken Nagasaka, Hiroyasu Umakoshi, Tomoki Ebata, M Nagino, Shinji Naganawa
  • Organizer: European Congress of Radiology 2017（ECR)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2017-03-01 – 2017-03-05
  • Int'l Joint Research
• [Presentation] Development of patient-specific three-dimensional-printed phantoms for artificial in vivo dosimetry. (2016)
  • Author(s): Takeshi Kamomae, Hidetoshi Shimizu, Takayoshi Nakaya, Kuniyasu Okudaira, Yoshikazu Miyake, Masataka Komori, Hiroshi Oguchi, Tomohiro Komada, Yoshiyuki Itoh, Shinji Naganawa
  • Organizer: International Conference on Medical Physios 2016
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2016-12-09 – 2016-12-12
  • Int'l Joint Research
• [Presentation] 頭部領域、MRIのおさえておきたい3つのポイント (2016)
  • Author(s): Shinji Naganawa
  • Organizer: Japanese Seminar in RSNA 2016
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-27 – 2016-12-02
  • Int'l Joint Research
• [Presentation] Intracellular volume fraction image on NODDI in diffuse axonal injury. (2016)
  • Author(s): Toshiaki Taoka, Hisashi Kawai, Toshiki Nakane, Kazuo Okuchi, Kimihiko Kichikawa, Shinji Naganawa, Toshiteru Miyasaka
  • Organizer: 102st Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA)
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-27 – 2016-12-02
  • Int'l Joint Research
• [Presentation] Detection of Primary and Metastatic Lesions of Urinary Tract Tumors by 18F-FLT PET/CT. (2016)
  • Author(s): Katsuhiko Kato, Yumiko Koshiba, Shinji Abe, Masayuki Honda,Keita Knimoto, Tetsuro Odagawa, Atsushi Murai, Shinji Naganawa
  • Organizer: 102st Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA)
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-27 – 2016-12-02
  • Int'l Joint Research
• [Presentation] Quantitative Follow-Up of Interstitial Pneumonia Using 3D-Curved High-Resolution CT Imaging Parallel to the Chest Wall. (2016)
  • Author(s): Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa
  • Organizer: 102st Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA)
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-27 – 2016-12-02
  • Int'l Joint Research
• [Presentation] Current state of MRI imaging for Meniere's disease (2016)
  • Author(s): Shinji Naganawa
  • Organizer: Korean Vongress of Radiology (KCR) 2016
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-09-21 – 2016-09-24
  • Int'l Joint Research
• [Presentation] Contrast enhancement of perivascular spaces in the basal ganglia. (2016)
  • Author(s): Shinji Naganawa
  • Organizer: German-Japanese Radiological Affilication 18th Workshop
  • Place of Presentation: Munich, German
  • Year and Date: 2016-06-02 – 2016-06-06
  • Int'l Joint Research
• [Remarks] 名古屋大学医学部放射線医学教室ホームページ
  • URL: https://www.med.nagoya-u.ac.jp/rad/
• [Remarks] 名古屋大学脳とこころの研究センターホームページ
  • URL: https://www.med.nagoya-u.ac.jp/noutokokoro/