2015 Fiscal Year Final Research Report
Use of high intensity focused ultrasound and photocatalytic nanoparticles for cancer treatment
| Project/Area Number |
25293268
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 超音波 / 酸化チタン / 癌細胞 / 光触媒 |
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| Outline of Final Research Achievements |
In this study, effects of high intensity focused ultrasound (HIFU) combined with photocatalytic titanium dioxide Silica (TiS) nanoparticles on human oral squamous cell line HSC-2 were investigated. Viability of HSC-2 cells after HIFU irradiation with various intensities in the presence or absence of TiS was measured immediately after the exposures in-vitro. Immediate effects of HIFU combined with TiS on solid tumors were also examined by histological study. Cytotoxic effect of HIFU+ TiS in-vitro was significantly higher than that of TiS or HIFU alone with the tendency to increase for higher HIFU intensity, duration, and TiS concentration in the suspension. In-vivo results showed significant necrosis and tissue damage in HIFU and HIFU+ TiS treated samples. However, penetration of TiS nanoparticles into the cell cytoplasm was only observed in HIFU+TiO2 treated tissues.
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| Free Research Field |
超音波治療
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