Basic and clinical research of the pathophysiology of vocal fold paralysis.

2016 Fiscal Year Final Research Report

• Project/Area Number: 25293349
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kumamoto University
• Principal Investigator: Yumoto Eiji 熊本大学, 大学院生命科学研究部(医), 名誉教授 (40116992)
• Co-Investigator(Renkei-kenkyūsha): SANUKI Tetsuji 熊本大学, 医学部附属病院 耳鼻咽喉科 頭頸部外科, 講師 (10335896) ; KUMAI Yoshihiko 熊本大学, 大学院生命科学研究部(医) 耳鼻咽喉科 頭頸部外科, 助教 (00555774) ; NISHIMOTO Kohei 熊本大学, 医学部附属病院 耳鼻咽喉科 頭頸部外科, 医員 (60535590)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 喉頭麻痺 / 筋衛星細胞 / ヒアルロン酸 / 三次元CT / 発声機能

Outline of Final Research Achievements

In basic research, the modulation of muscle satellite cells was analyzed using recurrent laryngeal nerve denervation models and reinnervation models. At the reinnervation model, de-activation of satellite cells was observed after reinnervation. Quantity of hyaluronic acid contained within lamina propria of vocal fold did not decrease, contrary to expectation that hyaluronic acid would decrease after denervation. Clinical research about the relationship of 3 dimension CT scan and vocal function revealed that the over adduction of vocal fold did not improve vocal function. Electromyogram of intrinsic laryngeal muscle of the vocal fold palsy patients who received the nerve muscle pedicle implantation surgery suggested that nerve muscle pedicle implantation improve the reinnervation of thyroarytenoid muscle.

Free Research Field

喉頭科学